JNK-Induced Apoptosis, Compensatory Growth, and Cancer Stem Cells

Overwhelming are a set of key stress-responsive kinases that mediate cell apoptosis, which is an important process for tumor suppression. However, JNKs have also been implicated in the malignant transformation and tumorigenesis of cells. This review attempts to reconcile these 2 contradictory functi...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2012-01, Vol.72 (2), p.379-386
Main Author: Chen, Fei
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Apoptosis
Apoptosis - physiology
Biological and medical sciences
Cancer
Cell Growth Processes - physiology
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Humans
JNK Mitogen-Activated Protein Kinases - metabolism
Medical sciences
Neoplastic Stem Cells - enzymology
Neoplastic Stem Cells - pathology
Pharmacology. Drug treatments
Signal Transduction
Stem cells
Transformation
Tumorigenesis
Tumors
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Summary:Overwhelming are a set of key stress-responsive kinases that mediate cell apoptosis, which is an important process for tumor suppression. However, JNKs have also been implicated in the malignant transformation and tumorigenesis of cells. This review attempts to reconcile these 2 contradictory functions of JNKs with recent discoveries on the role of JNKs in compensatory growth of neighboring cells and stem cells, which may provide new mechanistic understanding about the role of JNKs in the regulation of cancer stem cells and the pathogenesis of cancers.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.can-11-1982