Polyoxygenated cyclohexene derivatives from Monanthotaxis congoensis

• Published in: Phytochemistry (Oxford) 2012-02, Vol.74, p.185-189
• Main Authors: Starks, Courtney M., Williams, Russell B., Rice, Stephanie M., Norman, Vanessa L., Lawrence, Julie A., Goering, Matt G., O’Neil-Johnson, Mark, Hu, Jin-Feng, Eldridge, Gary R.
• Format: Article
• Language: English
• Subjects: Annonaceae; Annonaceae - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - therapeutic use; Cell Line, Tumor; Cell Proliferation - drug effects; Cyclohexenes - isolation & purification; Cyclohexenes - pharmacology; Cyclohexenes - therapeutic use; Cytotoxicity; Epoxy Compounds - chemistry; Epoxy Compounds - isolation & purification; Humans; Molecular Structure; Monanthotaxis congoensis; Neoplasms - drug therapy; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Polyoxygenated cyclohexene
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2011.10.014

A phytochemical investigation of Monanthotaxis congoensis afforded nine polyoxygenated cyclohexenes, one of which displayed moderate antiproliferative activity against NCI-H460 and M14 cancer cells. [Display omitted] ► Eight polyoxygenated cyclohexenes were isolated from Monanthotaxis congoensis. ► The compounds were isolated using a high-throughput natural products discovery approach. ► Structures were determined using NMR, MS, and optical rotation analyses. ► One compound displayed moderate antiproliferative activity against NCI-H460 and M14 cancer cells. A phytochemical investigation of Monanthotaxis congoensis afforded eight polyoxygenated cyclohexenes as well as the known crotepoxide. Structures were determined using NMR, MS, and optical rotation analyses. One compound displayed moderate antiproliferative activity against NCI-H460 and M14 cancer cells.