Protein adducts of malondialdehyde and 4-hydroxynonenal contribute to trichloroethene-mediated autoimmunity via activating Th17 cells: Dose– and time–response studies in female MRL+/+ mice

Highlights ► TCE exposure led to dose- and time-related increases in MDA-/HNE-protein adducts and their antibodies. ► Increased MDA-/HNE-adducts were associated with increases in serum autoantibodies. ► MDA-/HNE-albumin adducts trigger greater release of IL-17 and IL-21 from splenocytes of TCE-treat...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2012-02, Vol.292 (2-3), p.113-122
Main Authors: Wang, Gangduo, Wang, Jianling, Fan, Xiuzhen, Ansari, G.A.S, Khan, M. Firoze
Format: Article
Language:English
Subjects:
Aldehydes - immunology
Animals
Anti-MDA/HNE antibodies
antibodies
Autoantibodies
Autoimmune Diseases - chemically induced
Autoimmune Diseases - immunology
Autoimmunity
Autoimmunity - drug effects
Biological and medical sciences
blood serum
Dose-Response Relationship, Drug
drinking water
Emergency
Female
Glutathione - immunology
interleukin-17
Interleukin-17 - immunology
Interleukins - immunology
Kidney - enzymology
kidneys
malondialdehyde
Malondialdehyde - immunology
Medical sciences
Mice
Mice, Inbred MRL lpr
Oxidative stress
serum albumin
Solvents
splenocytes
Statistics, Nonparametric
Th17 cells
Toxicology
Trichloroethene
Trichloroethylene - toxicity
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Summary:Highlights ► TCE exposure led to dose- and time-related increases in MDA-/HNE-protein adducts and their antibodies. ► Increased MDA-/HNE-adducts were associated with increases in serum autoantibodies. ► MDA-/HNE-albumin adducts trigger greater release of IL-17 and IL-21 from splenocytes of TCE-treated mice. ► Results support that MDA-/HNE-modified proteins could contribute to an autoimmune response.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2011.12.001