Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects

Background Obesity is a result of a relative excess in energy intake over energy expenditure. These processes are controlled by genetic, environmental, psychological and biological factors. One of the factors involved in the regulation of food intake and satiety is dopaminergic signalling. A small n...

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Published in:EJNMMI research 2011-12, Vol.1 (1), p.37-37
Main Authors: de Weijer, Barbara A, van de Giessen, Elsmarieke, van Amelsvoort, Thérèse A, Boot, Erik, Braak, Breg, Janssen, Ignace M, van de Laar, Arnold, Fliers, Eric, Serlie, Mireille J, Booij, Jan
Format: Article
Language:English
Subjects:
Cardiac Imaging
Imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Oncology
Orthopedics
Radiology
Short Communication
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Summary:Background Obesity is a result of a relative excess in energy intake over energy expenditure. These processes are controlled by genetic, environmental, psychological and biological factors. One of the factors involved in the regulation of food intake and satiety is dopaminergic signalling. A small number of studies have reported that striatal dopamine D 2 /D 3 receptor [D2/3R] availability is lower in morbidly obese subjects. Methods To confirm the role of D2/3R in obesity, we measured striatal D2/3R availability, using [ 123 I]IBZM SPECT, in 15 obese women and 15 non-obese controls. Results Striatal D2/3R availability was 23% ( p = 0.028) lower in obese compared with non-obese women. Conclusion This study is an independent replication of the finding that severely obese subjects have lower striatal D2/3R availability. Our findings invigorate the evidence for lower striatal D2/3R availability in obesity and confirm the role of the striatal dopaminergic reward system in obesity.
ISSN:2191-219X
2191-219X
DOI:10.1186/2191-219X-1-37