Brain Natriuretic Peptide Predicts Functional Outcome in Ischemic Stroke

Elevated serum levels of brain natriuretic peptide (BNP) have been associated with cardioembolic stroke and increased poststroke mortality. We sought to determine whether BNP levels were associated with functional outcome after ischemic stroke. We measured BNP in consecutive patients aged ≥ 18 years...

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Bibliographic Details
Published in:Stroke (1970) 2012-02, Vol.43 (2), p.441-445
Main Authors: ROST, Natalia S, BIFFI, Alessandro, CLOONAN, Lisa, CHORBA, John, KELLY, Peter, GREER, David, ELLINOR, Patrick, FURIE, Karen L
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Brain - diagnostic imaging
Brain - pathology
Brain Ischemia - blood
Brain Ischemia - complications
Brain Ischemia - mortality
Cohort Studies
Female
Follow-Up Studies
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Heart Atria - pathology
Humans
Logistic Models
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Natriuretic Peptide, Brain - blood
Nervous system (semeiology, syndromes)
Neurology
Predictive Value of Tests
Recovery of Function
Stroke - blood
Stroke - complications
Stroke - mortality
Stroke Volume - physiology
Tomography, X-Ray Computed
Treatment Outcome
Vascular diseases and vascular malformations of the nervous system
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Summary:Elevated serum levels of brain natriuretic peptide (BNP) have been associated with cardioembolic stroke and increased poststroke mortality. We sought to determine whether BNP levels were associated with functional outcome after ischemic stroke. We measured BNP in consecutive patients aged ≥ 18 years admitted to our stroke unit between 2002 to 2005. BNP quintiles were used for analysis. Stroke subtypes were assigned using Trial of ORG 10172 in Acute Stroke Treatment criteria. Outcomes were measured as 6-month modified Rankin Scale score ("good outcome"=0-2 versus "poor") as well as mortality. Multivariate logistic regression was used to assess association between the quintiles of BNP and outcomes. Predictive performance of BNP as compared with clinical model alone was assessed by comparing receiver operating characteristic curves. Of 569 patients with ischemic stroke, 46% were female; mean age was 67.9 ± 15 years. In age- and gender-adjusted analysis, elevated BNP was associated with lower ejection fraction (P
ISSN:0039-2499
1524-4628
DOI:10.1161/strokeaha.111.629212