Translating cancer 'omics' to improved outcomes

The genomics era has yielded great advances in the understanding of cancer biology. At the same time, the immense complexity of the cancer genome has been revealed, as well as a striking heterogeneity at the whole-genome (or omics) level that exists between even histologically similar tumors. The va...

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Bibliographic Details
Published in:Genome research 2012-02, Vol.22 (2), p.188-195
Main Authors: Vucic, Emily A, Thu, Kelsie L, Robison, Keith, Rybaczyk, Leszek A, Chari, Raj, Alvarez, Carlos E, Lam, Wan L
Format: Article
Language:English
Subjects:
Animals
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Disease Models, Animal
Early Detection of Cancer
Genetic Association Studies
Genomics
Humans
Molecular Targeted Therapy
Mutation
Neoplasms - diagnosis
Neoplasms - genetics
Neoplasms - therapy
Prognosis
Proteomics
Signal Transduction
Translational Medical Research
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Summary:The genomics era has yielded great advances in the understanding of cancer biology. At the same time, the immense complexity of the cancer genome has been revealed, as well as a striking heterogeneity at the whole-genome (or omics) level that exists between even histologically similar tumors. The vast accrual and public availability of multi-omics databases with associated clinical annotation including tumor histology, patient response, and outcome are a rich resource that has the potential to lead to rapid translation of high-throughput omics to improved overall survival. We focus on the unique advantages of a multidimensional approach to genomic analysis in this new high-throughput omics age and discuss the implications of the changing cancer demographic to translational omics research.
ISSN:1088-9051
1549-5469
DOI:10.1101/gr.124354.111