A Collision Tumor Consisting of Granular Cell Tumor and Adenocarcinoma in the Uterus of an Aged Djungarian Hamster

A neoplastic nodular lesion consisting of an admixture of granular cell tumor and adenocarcinoma was found in the uterus of a 26-month-old Djungarian hamster. Neoplastic cells of the uterine adenocarcinoma showed an epithelial nature in their growth patterns and by cytokeratin-immunopositive reactio...

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Bibliographic Details
Published in:Journal of Toxicologic Pathology 2011, Vol.24(4), pp.233-237
Main Authors: Golbar, Hossain M., Izawa, Takeshi, Kuwamura, Mitsuru, Okamura, Kensaku, Fujita, Daisuke, Tagami, Yukari, Sasai, Hiroshi, Yamate, Jyoji
Format: Article
Language:English
Subjects:
Actin
Adenocarcinoma
Case Report
collision tumor
Cytoplasm
Desmin
Electron microscopy
granular cell
Growth patterns
hamster
Leukocytes (eosinophilic)
Lysosomes
Macrophages
Phagosomes
Pleomorphism
Smooth muscle
Tumors
Uterus
Vimentin
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Summary:A neoplastic nodular lesion consisting of an admixture of granular cell tumor and adenocarcinoma was found in the uterus of a 26-month-old Djungarian hamster. Neoplastic cells of the uterine adenocarcinoma showed an epithelial nature in their growth patterns and by cytokeratin-immunopositive reaction, exhibiting nuclear pleomorphism. The granular cells had an abundant amount of fine granular eosinophilic cytoplasm and eccentric or central nuclei with no nuclear atypia; the granular structures were positive for periodic acid-Schiff with diastase resistance and were confirmed as lysosomes/autophagosomes by electron microscopy; immunohistochemically, the cells reacted to desmin, vimentin and α-smooth muscle actin and negatively for neurogenic, histiocyte/macrophage or epithelial markers, indicating smooth muscle origin. Because these tumors were generated from different cell origins, a diagnosis of collision tumor was made.
ISSN:0914-9198
1881-915X
1347-7404
DOI:10.1293/tox.24.233