CCL5-independent helper T lymphocyte responses to immuno-dominant pneumococcal surface protein A epitopes

Highlights ► PspA is a candidate vaccine antigen against pneumococcal disease. ► Certain individuals susceptible to pneumococcal infection have ccl5 polymorphisms. ► These variances limit expression of CCL5, which is needed for pneumococcal immunity. ► We show HTL responses to PspA199-246 are largel...

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Bibliographic Details
Published in:Vaccine 2012-02, Vol.30 (6), p.1181-1190
Main Authors: Singh, Rajesh, Singh, Shailesh, Briles, David E, Taub, Dennis D, Hollingshead, Susan K, Lillard, James W
Format: Article
Language:English
Subjects:
adaptive immunity
Allergy and Immunology
Amino acids
Animals
Antigens
Bacterial Proteins - immunology
CD4-positive T-lymphocytes
Chemokine CCL5 - deficiency
Chemokine CCL5 - immunology
Chemokines
Disease
epitopes
Epitopes - immunology
Female
Flow cytometry
genetic polymorphism
HTL epitope
infectious diseases
interferon-gamma
interleukin-10
Laboratory animals
lymph nodes
Lymphocytes
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Peptides
Pneumonia
Proteins
Review boards
secretion
Spleen
Streptococcus infections
Streptococcus pneumoniae
Streptococcus pneumoniae - immunology
surface proteins
T helper cytokine
T-Lymphocytes, Helper-Inducer - immunology
vaccines
virulence
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Summary:Highlights ► PspA is a candidate vaccine antigen against pneumococcal disease. ► Certain individuals susceptible to pneumococcal infection have ccl5 polymorphisms. ► These variances limit expression of CCL5, which is needed for pneumococcal immunity. ► We show HTL responses to PspA199-246 are largely resistant to CCL5 deficiency.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.12.020