Sodium Intake, ACE Inhibition, and Progression to ESRD

High sodium intake limits the antihypertensive and antiproteinuric effects of angiotensin-converting enzyme (ACE) inhibitors in patients with CKD; however, whether dietary sodium also associates with progression to ESRD is unknown. We conducted a post hoc analysis of the first and second Ramipril Ef...

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Bibliographic Details
Published in:Journal of the American Society of Nephrology 2012-01, Vol.23 (1), p.165-173
Main Authors: VEGTER, Stefan, PERNA, Annalisa, POSTMA, Maarten J, NAVIS, Gerjan, REMUZZI, Giuseppe, RUGGENENTI, Piero
Format: Article
Language:English
Subjects:
Adult
Aged
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Biological and medical sciences
Clinical Research
Female
Humans
Kidney Failure, Chronic - etiology
Kidney Failure, Chronic - prevention & control
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Proteinuria - drug therapy
Proteinuria - etiology
Ramipril - therapeutic use
Renal failure
Sodium - urine
Sodium, Dietary - adverse effects
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Summary:High sodium intake limits the antihypertensive and antiproteinuric effects of angiotensin-converting enzyme (ACE) inhibitors in patients with CKD; however, whether dietary sodium also associates with progression to ESRD is unknown. We conducted a post hoc analysis of the first and second Ramipril Efficacy in Nephropathy trials to evaluate the association of sodium intake with proteinuria and progression to ESRD among 500 CKD patients without diabetes who were treated with ramipril (5 mg/d) and monitored with serial 24-hour urinary sodium and creatinine measurements. Urinary sodium/creatinine excretion defined low (
ISSN:1046-6673
1533-3450
DOI:10.1681/asn.2011040430