Two modes of longe-range orientation of DNA bases realized upon compaction

Formation of compact particles from linear DNA-anthracycline complexesis accompanied by appearance of intense bands in the CD spectra in the region of absorption of DNA bases (UV-region) and in the region of absorption of anthracycline chromophores(visible region). The intense (positive or negative)...

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Bibliographic Details
Published in:Nucleic acids research 1981-02, Vol.9 (3), p.743-752
Main Authors: Yevdokimov, Yu.M., Salyanov, V.I., Berg, H.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents
Antibiotics, Antineoplastic
Base Sequence
Cattle
Chemical Phenomena
Chemistry
Circular Dichroism
DNA - analysis
Glycosides
Naphthacenes
Polyethylene Glycols
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Summary:Formation of compact particles from linear DNA-anthracycline complexesis accompanied by appearance of intense bands in the CD spectra in the region of absorption of DNA bases (UV-region) and in the region of absorption of anthracycline chromophores(visible region). The intense (positive or negative) bands in the region of anthracycline absorption demonstrate an order edhelical location of anfhracycline molecules on the DNA template. This fact, in its turn, is related to formation of the DNA superstructure in PEG-containingvater-salt solutions with a long-range orientation of nitrogen bases. Possible types of DNA super structures and the relation between the local-and the Long-range order of bases in the DNA super structure are discussed.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/9.3.743