Multicentric Castleman disease in an HHV8-infected child born to consanguineous parents with systematic review

Childhood multicentric Castleman disease (MCD) is a rare and unexplained lymphoproliferative disorder. We report a human herpesvirus-8 (HHV-8)-infected child, born to consanguineous Comorian parents, who displayed isolated MCD in the absence of any known immunodeficiency. We also systematically revi...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2012-01, Vol.129 (1), p.e199-e203
Main Authors: Leroy, Sandrine, Moshous, Despina, Cassar, Olivier, Reguerre, Yves, Byun, Minji, Pedergnana, Vincent, Canioni, Danielle, Gessain, Antoine, Oksenhendler, Eric, Fieschi, Claire, Mahlaoui, Nizar, Rivière, Jean-Pierre, Herbigneaux, Rose-Marie, Muszlak, Matthias, Arnaud, Jean-Pierre, Fischer, Alain, Picard, Capucine, Blanche, Stéphane, Plancoulaine, Sabine, Casanova, Jean-Laurent
Format: Article
Language:English
Subjects:
Case Reports
Case studies
Castleman Disease - complications
Castleman Disease - pathology
Castleman Disease - virology
Causes of
Child
Consanguinity
Control
Female
Giant Lymph Node Hyperplasia/complications
Giant Lymph Node Hyperplasia/pathology
Giant Lymph Node Hyperplasia/virology
Health aspects
Herpesviridae Infections - complications
Herpesviridae Infections - immunology
Herpesvirus 8, Human
Herpesviruses
Human health and pathology
Humans
Life Sciences
Lymphoproliferative disorders
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Summary:Childhood multicentric Castleman disease (MCD) is a rare and unexplained lymphoproliferative disorder. We report a human herpesvirus-8 (HHV-8)-infected child, born to consanguineous Comorian parents, who displayed isolated MCD in the absence of any known immunodeficiency. We also systematically review the clinical features of the 32 children previously reported with isolated and unexplained MCD. The characteristics of this patient and the geographic areas of origin of most previous cases suggest that pediatric MCD is associated with HHV-8 infection. Moreover, as previously suggested for Kaposi sarcoma, MCD in childhood may result from inborn errors of immunity to HHV-8 infection.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2010-2739