Relationship of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality in older community-dwelling adults

• Published in: European journal of clinical nutrition 2010-02, Vol.64 (2), p.203-209
• Main Authors: Semba, R.D, Houston, D.K, Bandinelli, S, Sun, K, Cherubini, A, Cappola, A.R, Guralnik, J.M, Ferrucci, L
• Format: Article
• Language: English
• Subjects: 25-hydroxycholecalciferol; 25-Hydroxyvitamin D; Adults; Aged; Aged, 80 and over; Aging; Biological and medical sciences; Biomedical materials; blood serum; Calciferol; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - mortality; Cause of Death; Clinical Nutrition; cohort studies; Complications and side effects; Confidence intervals; Demographic aspects; diet-related diseases; Education; elderly; elderly nutrition; Epidemiology; Fatalities; Feeding. Feeding behavior; Female; Food and nutrition; Fractures; Fundamental and applied biological sciences. Psychology; Geriatrics; Health aspects; human diseases; Humans; Internal Medicine; Italy; Italy - epidemiology; Male; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Mortality; Muscle strength; Nutrition research; nutritional status; Older people; original-article; Osteoporosis; Physical activity; Population studies; prediction; Proportional Hazards Models; Prospective Studies; Public Health; Residence Characteristics; Risk; Risk factors; Statistical models; Statistics; Treatment Outcome; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D deficiency; Vitamin D Deficiency - blood; Vitamin D Deficiency - mortality; vitamin deficiencies; Vitamin deficiency
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/ejcn.2009.140

Background/Objectives: Vitamin D deficiency is associated with cardiovascular disease, osteoporosis, poor muscle strength, falls, fractures and mortality. Although older adults are at a higher risk of vitamin D deficiency, the relationship of serum 25-hydroxyvitamin D (25(OH)D) with all-cause and cardiovascular disease mortality has not been well characterized in the elderly. We hypothesized that low serum 25(OH)D levels predicted mortality in older adults. Subjects/Methods: Serum 25(OH)D as well as all-cause and cardiovascular disease mortality were examined in 1006 adults, aged 65 years, who participated in the InCHIANTI (Invecchiare in Chianti, Aging in the Chianti Area) study, a population-based, prospective cohort study of aging in Tuscany, Italy. Serum 25(OH)D levels were measured at the time of enrollment in 1998–1999, and participants were followed up for mortality. Results: During 6.5 years of follow-up, 228 (22.7%) participants died, of whom 107 died due to cardiovascular diseases. Compared with participants in the highest quartile of serum 25(OH)D (>26.5 ng/ml) (to convert to nmol/l, multiply by 2.496), those in the lowest quartile (