Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater Adiposity

The central nervous system (CNS) plays key role in the homeostatic regulation of body weight. Satiation and adiposity signals, providing acute and chronic information about available fuel, are produced in the periphery and act in the brain to influence energy intake and expenditure, resulting in the...

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Bibliographic Details
Published in:Cell metabolism 2012-02, Vol.15 (2), p.137-149
Main Authors: Ryan, Karen K., Woods, Stephen C., Seeley, Randy J.
Format: Article
Language:English
Subjects:
Adipose tissue
Adiposity - physiology
Animals
Body weight
Brain
Central nervous system
Central Nervous System - physiology
Circuits
Dietary Fats - metabolism
Endoplasmic Reticulum Stress - physiology
Energy intake
Food
Food Supply
Fuels
High fat diet
Homeostasis - physiology
Humans
Insulin Resistance - physiology
Leptin - metabolism
Models, Biological
Obesity
Obesity - epidemiology
Obesity - physiopathology
Obesity - prevention & control
Protein Kinase C - metabolism
Satiety
Therapeutic applications
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Summary:The central nervous system (CNS) plays key role in the homeostatic regulation of body weight. Satiation and adiposity signals, providing acute and chronic information about available fuel, are produced in the periphery and act in the brain to influence energy intake and expenditure, resulting in the maintenance of stable adiposity. Diet-induced obesity (DIO) does not result from a failure of these central homeostatic circuits. Rather, the threshold for defended adiposity is increased in environments providing ubiquitous access to palatable, high-fat foods, making it difficult to achieve and maintain weight loss. Consequently, mechanisms by which nutritional environments interact with central homeostatic circuits to influence the threshold for defended adiposity represent critical targets for therapeutic intervention.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2011.12.013