Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental, Psychomotor, and Behavioral Development at 3 Years of Age

• Published in: Environmental health perspectives 2012-02, Vol.120 (2), p.290-295
• Main Authors: Whyatt, Robin M., Liu, Xinhua, Rauh, Virginia A., Calafat, Antonia M., Just, Allan C., Hoepner, Lori, Diaz, Diurka, Quinn, James, Adibi, Jennifer, Perera, Frederica P., Factor-Litvak, Pam
• Format: Article
• Language: English
• Subjects: Adult; Behavior; Biological and medical sciences; Chemical hazards; Child Behavior - drug effects; Child development; Child Development - drug effects; Child, Preschool; Children; Children's Health; Environment. Living conditions; Environmental aspects; Environmental health; Female; Health aspects; Humans; Linear Models; Logistic Models; Maternal Exposure; Medical sciences; Mental concentration; Metabolites; Neuropsychological Tests; New York City - epidemiology; Odds Ratio; Phthalates; Phthalic Acids - metabolism; Phthalic Acids - toxicity; Phthalic Acids - urine; Pregnancy; Pregnant women; Prenatal Exposure Delayed Effects - epidemiology; Psychomotor Performance - drug effects; Public health. Hygiene; Public health. Hygiene-occupational medicine; Sex linked differences; Toxicology; Urban Health; Urine; Young Adult
• ISSN: 0091-6765; 1552-9924
• DOI: 10.1289/ehp.1103705

Background: Research suggests that prenatal phthalate exposures affect child executive function and behavior. Objective: We evaluated associations between phthalate metabolite concentrations in maternal prenatal urine and mental, motor, and behavioral development in children at 3 years of age. Methods: Mono-n-butyl phthalate (MnBP), monobenzyl phthalate (MBzP), monoisobutyl phthalate (MiBP), and four di-2-ethylhexyl phthalate metabolites were measured in a spot urine sample collected from 319 women during the third trimester. When children were 3 years of age, the Mental Development Index (MDI) and Psychomotor Development Index (PDI) were measured using the Bayiey Scales of Infant Development II, and behavior problems were assessed by maternal report on the Child Behavior Checklist. Results: Child PDI scores decreased with increasing log, MnBP [estimated adjusted ß-coefficient = -2.81; 95% confidence interval (CI): -4.63, -1.0] and log, MiBP (ß = -2.28; 95% CI: -3.90, -0.67); odds of motor delay increased significantly [per log, MnBP: estimated adjusted odds ratio (OR) = 1.64; 95% CI: 1.10, 2.44; per log, MiBP: adjusted OR = 1.82; 95% CI: 1.24, 2.66]. In girls, MDI scores decreased with increasing log, MnBP (ß = -2.67; 95% CI: -4.70, -0.65); the child sex difference in odds of mental delay was significant (p = 0.037). The ORs for clinically withdrawn behavior were 2.23 (95% CI: 1.27, 3.92) and 1.57 (95% CI: 1.07, 2.31) per log, unit increase in MnBP and MBzP, respectively, for clinically internalizing behaviors, the OR was 1.43 (95% CI: 1.01, 1.90) per log, unit increase in MBzP. Significant child sex differences were seen in associations between MnBP and MBzP and behaviors in internalizing domains (p < 0.05). Conclusion: Certain prenatal phthalate exposures may decrease child mental and motor development and increase internalizing behaviors.