The anabolic response to resistance exercise and a protein-rich meal is not diminished by age

Objectives The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described. However, it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss. To this end, we sought to d...

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Published in:The Journal of nutrition, health & aging health & aging, 2011-05, Vol.15 (5), p.376-381
Main Authors: Symonsi, T. B., Sheffield-Moore, M., Mamerow, M. M., Wolfe, R. R., Paddon-Jones, Douglas
Format: Article
Language:English
Subjects:
Adult
Aged
Aging
Aging - physiology
Biological and medical sciences
Biopsy
Dietary Proteins - pharmacology
Exercise - physiology
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Geriatrics/Gerontology
Humans
Male
Meat
Medicine
Medicine & Public Health
Muscle Proteins - biosynthesis
Neurosciences
Nutrition
Phenylalanine - metabolism
Primary Care Medicine
Quadriceps Muscle - metabolism
Quadriceps Muscle - physiology
Quality of Life Research
Resistance Training
Response to Exercise and Protein is Not Reduced by Age
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Objectives The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described. However, it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss. To this end, we sought to determine if the synergistic response to a bout of resistance exercise and a protein-rich lean beef meal was altered by age. Setting The University of Texas Medical Branch, Clinical Research Center, Galveston, Texas. Participants Healthy young (n=7, 29±3 y) and older (n=7, 67±2 y) adults. Design Mixed muscle fractional synthesis rate (FSR) was calculated during a 3 h post-absorptive/rest period and again during a 5 h period following ingestion of a protein-rich meal (340 g lean beef) and bout of resistance exercise (6 sets of 8 repetitions of isotonic knee extension exercise at 80% one repetition maximum). Measurements Venous blood samples and vastus lateralis muscle biopsy samples were obtained during a primed (2.0 µmol/kg) constant infusion (0.08 µmol·kg −1 min 1 ) of L- [ring- 13 C 6 ] phenylalanine. Results Mixed muscle FSR increased by approximately 108% in both young [pre: 0.073+0.008; post: 0.156±0.021 (SE) %/h, p
ISSN:1279-7707
1760-4788
DOI:10.1007/s12603-010-0319-z