Adult patients are more catabolic than children during acute phase after burn injury: a retrospective analysis on muscle protein kinetics

Purpose This study was performed to determine if there is an age-related specificity in the response of muscle protein metabolism to severe burn injury during acute hospitalization. This is a retrospective analysis of previously published data. Methods Nineteen adult and 58 pediatric burn-injured pa...

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Bibliographic Details
Published in:Intensive care medicine 2011-08, Vol.37 (8), p.1317-1322
Main Authors: Tuvdendorj, Demidmaa, Chinkes, David L., Zhang, Xiao-Jun, Ferrando, Arny A., Elijah, Itoro E., Mlcak, Ronald P., Finnerty, Celeste C., Wolfe, Robert R., Herndon, David N.
Format: Article
Language:English
Subjects:
Adult
Adults
Age
Age Factors
Analysis
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthesiology
Biological and medical sciences
Biopsy
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Burns
Burns - blood
Burns - metabolism
Burns and scalds
Child
Critical Care Medicine
Emergency Medicine
Enteral nutrition
Female
Herndon, David N
Humans
Intensive
Intensive care medicine
Kinetics
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolism
Muscle Proteins - metabolism
Original
Pain Medicine
Pediatrics
Phenylalanine
Physiological aspects
Pneumology/Respiratory System
Protein synthesis
Proteins
Retrospective Studies
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Wolfe, Robert R
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Summary:Purpose This study was performed to determine if there is an age-related specificity in the response of muscle protein metabolism to severe burn injury during acute hospitalization. This is a retrospective analysis of previously published data. Methods Nineteen adult and 58 pediatric burn-injured patients (age 43.3 ± 14.3 vs. 7.2 ± 5.3 years, adult vs. children) participated in stable isotope [ ring - 2 H 5 ]phenylalanine (Phe) infusion studies. Femoral arterial and venous blood samples and muscle biopsy samples were collected throughout the study. Data are presented as means ± standard deviation (SD). A p value less than 0.05 was considered statistically significant. Results Muscle net protein balance (NB) was higher in children (adult vs. children, −43 ± 61 vs. 8 ± 68 nmol Phe/min/100 ml leg volume, p  
ISSN:0342-4642
1432-1238
DOI:10.1007/s00134-011-2223-3