Existence of Manserin, a Secretogranin II–Derived Neuropeptide, in the Rat Inner Ear: Relevance to Modulation of Auditory and Vestibular System

• Published in: The journal of histochemistry and cytochemistry 2012-01, Vol.60 (1), p.69-75
• Main Authors: Ida-Eto, Michiru, Oyabu, Akiko, Ohkawara, Takeshi, Tashiro, Yasura, Narita, Naoko, Narita, Masaaki
• Format: Article
• Language: English
• Subjects: Animals; Auditory Pathways - metabolism; Ear, Inner - metabolism; Immunohistochemistry; Male; Neuropeptides - metabolism; Organ of Corti - metabolism; Organ Specificity; Peptide Fragments - metabolism; Rats; Rats, Wistar; Secretogranin II - metabolism; Spiral Ganglion - cytology; Spiral Ganglion - metabolism; Vestibule, Labyrinth - metabolism
• ISSN: 0022-1554; 1551-5044
• DOI: 10.1369/0022155411425688

Manserin is a 40–amino acid neuropeptide derived from rat brain. Manserin has been shown to distribute in the neuroendocrine system, such as the pituitary and adrenal glands, but it has been little studied in other organs. In this study, the authors examined localization of manserin in the inner ear of the adult Wistar rat using immunohistochemical analyses. Manserin immunoreactivity was detected in the neuronal terminals of the organ of Corti and type II spiral ganglion cells. In addition to being identified in the auditory system, manserin was detected at the synapses of the vestibular system, such as saccule, utricle, and semicircular canal. These results suggest that inner ear manserin may be involved in the function of peripheral auditory and vestibular systems.