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Early post-operative interleukin-6 and tumor necrosis factor-α levels after single-port laparoscopic varicocelectomy in children
Purpose Laparoendoscopic single-site surgery has recently been described in children and regarded as an improved technology leading to less pain and better cosmetic outcome. Compared to the traditional three-port method, it is not known if the single-port method is less invasive. The aim of this stu...
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| Published in: | Pediatric surgery international 2012-03, Vol.28 (3), p.281-286 |
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| Main Authors: | , , , , , |
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| container_end_page | 286 |
| container_issue | 3 |
| container_start_page | 281 |
| container_title | Pediatric surgery international |
| container_volume | 28 |
| creator | Hao, Wei Chan, Ivy H. Y. Liu, XueLai Tang, Paula M. Y. Tam, Paul K. H. Wong, Kenneth K. Y. |
| description | Purpose
Laparoendoscopic single-site surgery has recently been described in children and regarded as an improved technology leading to less pain and better cosmetic outcome. Compared to the traditional three-port method, it is not known if the single-port method is less invasive. The aim of this study was thus to investigate the post-operative acute inflammatory response in order to evaluate surgical stress in the two surgical approaches in children.
Methods
A prospective, single blinded, case-control study was carried out. Thirteen male patients who presented with unilateral varicocele were divided into two groups. Six children underwent single-port laparoscopic procedure, while the other seven children underwent three-port laparoscopic procedure. Pre-operative and post-operative blood samples were taken for the measurement of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) using ELISA. Demographics including the operation time, and complications were recorded. Data between the two groups were analyzed using unpaired
t
-test and a
p
value of |
| doi_str_mv | 10.1007/s00383-011-3011-4 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3284665</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>923578230</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-4b0f3acbcb7bf307f63f9764efd99da8a025dd32833d026454d7a86f693ceb833</originalsourceid><addsrcrecordid>eNp9kc1u3CAUhVHVqpn8PEA3FbuuSMFgYzaVqij9kSJlk64RxpcJKQYX7JFmmUfqi_SZymjSqN10AxL3nHMv90PoDaOXjFL5vlDKe04oY4QfDvECbZjgkqie8ZdoQ5lUhPK2P0GnpTxQSnveqdfopGFKCSr7DXq8Njns8ZzKQtIM2Sx-B9jHBXKA9buPpMMmjnhZp5RxBJtT8QU7Y5eUya-fOMAOQsHGVQcuPm4DkDnlBQczmyq2afYW70z2NlkIUH3TvjbA9t6HMUM8R6-cCQUunu4z9O3T9d3VF3Jz-_nr1ccbYoVgCxEDddzYwQ5ycJxK13GnZCfAjUqNpje0aceRNz3nI2060YpRmr5zneIWhvp6hj4cc-d1mGC0EJdsgp6zn0ze62S8_rcS_b3epp2umaLr2hrw7ikgpx8rlEVPvtQvBRMhrUWrhreybzitSnZUHrZVMrjnLozqAzl9JKcrNH0gp0X1vP17vGfHH1RV0BwFpZbiFrJ-SGuOdWX_Sf0NTISpZA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>923578230</pqid></control><display><type>article</type><title>Early post-operative interleukin-6 and tumor necrosis factor-α levels after single-port laparoscopic varicocelectomy in children</title><source>Springer Link</source><creator>Hao, Wei ; Chan, Ivy H. Y. ; Liu, XueLai ; Tang, Paula M. Y. ; Tam, Paul K. H. ; Wong, Kenneth K. Y.</creator><creatorcontrib>Hao, Wei ; Chan, Ivy H. Y. ; Liu, XueLai ; Tang, Paula M. Y. ; Tam, Paul K. H. ; Wong, Kenneth K. Y.</creatorcontrib><description>Purpose
Laparoendoscopic single-site surgery has recently been described in children and regarded as an improved technology leading to less pain and better cosmetic outcome. Compared to the traditional three-port method, it is not known if the single-port method is less invasive. The aim of this study was thus to investigate the post-operative acute inflammatory response in order to evaluate surgical stress in the two surgical approaches in children.
Methods
A prospective, single blinded, case-control study was carried out. Thirteen male patients who presented with unilateral varicocele were divided into two groups. Six children underwent single-port laparoscopic procedure, while the other seven children underwent three-port laparoscopic procedure. Pre-operative and post-operative blood samples were taken for the measurement of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) using ELISA. Demographics including the operation time, and complications were recorded. Data between the two groups were analyzed using unpaired
t
-test and a
p
value of <0.05 was taken as statistically significant.
Results
The mean age of patients was 14.5 years (range 12–19 years). There was no significant difference between the two groups in terms of operative time, nor there was any complication recorded. The change in serum TNF-α and IL-6 concentrations pre- and post-operatively between the single-port group and three-port group was not statistically significant. Overall, patients in the two groups showed excellent satisfaction in terms of post-operative cosmesis.
Conclusion
Single-port laparoscopic varicocelectomy is safe, effective and produces excellent cosmesis with minimal surgical stress.</description><identifier>ISSN: 0179-0358</identifier><identifier>EISSN: 1437-9813</identifier><identifier>DOI: 10.1007/s00383-011-3011-4</identifier><identifier>PMID: 21994078</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Biomarkers - blood ; Child ; Enzyme-Linked Immunosorbent Assay ; Equipment Design ; Follow-Up Studies ; Humans ; Interleukin-6 - blood ; Laparoscopes ; Laparoscopy - methods ; Male ; Medicine ; Medicine & Public Health ; Original ; Original Article ; Pediatric Surgery ; Pediatrics ; Postoperative Period ; Prospective Studies ; Stress, Physiological - physiology ; Surgery ; Time Factors ; Tumor Necrosis Factor-alpha - blood ; Urologic Surgical Procedures, Male - instrumentation ; Varicocele - blood ; Varicocele - diagnosis ; Varicocele - surgery</subject><ispartof>Pediatric surgery international, 2012-03, Vol.28 (3), p.281-286</ispartof><rights>The Author(s) 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-4b0f3acbcb7bf307f63f9764efd99da8a025dd32833d026454d7a86f693ceb833</citedby><cites>FETCH-LOGICAL-c441t-4b0f3acbcb7bf307f63f9764efd99da8a025dd32833d026454d7a86f693ceb833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21994078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hao, Wei</creatorcontrib><creatorcontrib>Chan, Ivy H. Y.</creatorcontrib><creatorcontrib>Liu, XueLai</creatorcontrib><creatorcontrib>Tang, Paula M. Y.</creatorcontrib><creatorcontrib>Tam, Paul K. H.</creatorcontrib><creatorcontrib>Wong, Kenneth K. Y.</creatorcontrib><title>Early post-operative interleukin-6 and tumor necrosis factor-α levels after single-port laparoscopic varicocelectomy in children</title><title>Pediatric surgery international</title><addtitle>Pediatr Surg Int</addtitle><addtitle>Pediatr Surg Int</addtitle><description>Purpose
Laparoendoscopic single-site surgery has recently been described in children and regarded as an improved technology leading to less pain and better cosmetic outcome. Compared to the traditional three-port method, it is not known if the single-port method is less invasive. The aim of this study was thus to investigate the post-operative acute inflammatory response in order to evaluate surgical stress in the two surgical approaches in children.
Methods
A prospective, single blinded, case-control study was carried out. Thirteen male patients who presented with unilateral varicocele were divided into two groups. Six children underwent single-port laparoscopic procedure, while the other seven children underwent three-port laparoscopic procedure. Pre-operative and post-operative blood samples were taken for the measurement of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) using ELISA. Demographics including the operation time, and complications were recorded. Data between the two groups were analyzed using unpaired
t
-test and a
p
value of <0.05 was taken as statistically significant.
Results
The mean age of patients was 14.5 years (range 12–19 years). There was no significant difference between the two groups in terms of operative time, nor there was any complication recorded. The change in serum TNF-α and IL-6 concentrations pre- and post-operatively between the single-port group and three-port group was not statistically significant. Overall, patients in the two groups showed excellent satisfaction in terms of post-operative cosmesis.
Conclusion
Single-port laparoscopic varicocelectomy is safe, effective and produces excellent cosmesis with minimal surgical stress.</description><subject>Adolescent</subject><subject>Biomarkers - blood</subject><subject>Child</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Equipment Design</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Laparoscopes</subject><subject>Laparoscopy - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original</subject><subject>Original Article</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Postoperative Period</subject><subject>Prospective Studies</subject><subject>Stress, Physiological - physiology</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Urologic Surgical Procedures, Male - instrumentation</subject><subject>Varicocele - blood</subject><subject>Varicocele - diagnosis</subject><subject>Varicocele - surgery</subject><issn>0179-0358</issn><issn>1437-9813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u3CAUhVHVqpn8PEA3FbuuSMFgYzaVqij9kSJlk64RxpcJKQYX7JFmmUfqi_SZymjSqN10AxL3nHMv90PoDaOXjFL5vlDKe04oY4QfDvECbZjgkqie8ZdoQ5lUhPK2P0GnpTxQSnveqdfopGFKCSr7DXq8Njns8ZzKQtIM2Sx-B9jHBXKA9buPpMMmjnhZp5RxBJtT8QU7Y5eUya-fOMAOQsHGVQcuPm4DkDnlBQczmyq2afYW70z2NlkIUH3TvjbA9t6HMUM8R6-cCQUunu4z9O3T9d3VF3Jz-_nr1ccbYoVgCxEDddzYwQ5ycJxK13GnZCfAjUqNpje0aceRNz3nI2060YpRmr5zneIWhvp6hj4cc-d1mGC0EJdsgp6zn0ze62S8_rcS_b3epp2umaLr2hrw7ikgpx8rlEVPvtQvBRMhrUWrhreybzitSnZUHrZVMrjnLozqAzl9JKcrNH0gp0X1vP17vGfHH1RV0BwFpZbiFrJ-SGuOdWX_Sf0NTISpZA</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Hao, Wei</creator><creator>Chan, Ivy H. Y.</creator><creator>Liu, XueLai</creator><creator>Tang, Paula M. Y.</creator><creator>Tam, Paul K. H.</creator><creator>Wong, Kenneth K. Y.</creator><general>Springer-Verlag</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120301</creationdate><title>Early post-operative interleukin-6 and tumor necrosis factor-α levels after single-port laparoscopic varicocelectomy in children</title><author>Hao, Wei ; Chan, Ivy H. Y. ; Liu, XueLai ; Tang, Paula M. Y. ; Tam, Paul K. H. ; Wong, Kenneth K. Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-4b0f3acbcb7bf307f63f9764efd99da8a025dd32833d026454d7a86f693ceb833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Biomarkers - blood</topic><topic>Child</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Equipment Design</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Laparoscopes</topic><topic>Laparoscopy - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original</topic><topic>Original Article</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Postoperative Period</topic><topic>Prospective Studies</topic><topic>Stress, Physiological - physiology</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Urologic Surgical Procedures, Male - instrumentation</topic><topic>Varicocele - blood</topic><topic>Varicocele - diagnosis</topic><topic>Varicocele - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hao, Wei</creatorcontrib><creatorcontrib>Chan, Ivy H. Y.</creatorcontrib><creatorcontrib>Liu, XueLai</creatorcontrib><creatorcontrib>Tang, Paula M. Y.</creatorcontrib><creatorcontrib>Tam, Paul K. H.</creatorcontrib><creatorcontrib>Wong, Kenneth K. Y.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric surgery international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hao, Wei</au><au>Chan, Ivy H. Y.</au><au>Liu, XueLai</au><au>Tang, Paula M. Y.</au><au>Tam, Paul K. H.</au><au>Wong, Kenneth K. Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early post-operative interleukin-6 and tumor necrosis factor-α levels after single-port laparoscopic varicocelectomy in children</atitle><jtitle>Pediatric surgery international</jtitle><stitle>Pediatr Surg Int</stitle><addtitle>Pediatr Surg Int</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>28</volume><issue>3</issue><spage>281</spage><epage>286</epage><pages>281-286</pages><issn>0179-0358</issn><eissn>1437-9813</eissn><abstract>Purpose
Laparoendoscopic single-site surgery has recently been described in children and regarded as an improved technology leading to less pain and better cosmetic outcome. Compared to the traditional three-port method, it is not known if the single-port method is less invasive. The aim of this study was thus to investigate the post-operative acute inflammatory response in order to evaluate surgical stress in the two surgical approaches in children.
Methods
A prospective, single blinded, case-control study was carried out. Thirteen male patients who presented with unilateral varicocele were divided into two groups. Six children underwent single-port laparoscopic procedure, while the other seven children underwent three-port laparoscopic procedure. Pre-operative and post-operative blood samples were taken for the measurement of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) using ELISA. Demographics including the operation time, and complications were recorded. Data between the two groups were analyzed using unpaired
t
-test and a
p
value of <0.05 was taken as statistically significant.
Results
The mean age of patients was 14.5 years (range 12–19 years). There was no significant difference between the two groups in terms of operative time, nor there was any complication recorded. The change in serum TNF-α and IL-6 concentrations pre- and post-operatively between the single-port group and three-port group was not statistically significant. Overall, patients in the two groups showed excellent satisfaction in terms of post-operative cosmesis.
Conclusion
Single-port laparoscopic varicocelectomy is safe, effective and produces excellent cosmesis with minimal surgical stress.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21994078</pmid><doi>10.1007/s00383-011-3011-4</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0179-0358 |
| ispartof | Pediatric surgery international, 2012-03, Vol.28 (3), p.281-286 |
| issn | 0179-0358 1437-9813 |
| language | eng |
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| source | Springer Link |
| subjects | Adolescent Biomarkers - blood Child Enzyme-Linked Immunosorbent Assay Equipment Design Follow-Up Studies Humans Interleukin-6 - blood Laparoscopes Laparoscopy - methods Male Medicine Medicine & Public Health Original Original Article Pediatric Surgery Pediatrics Postoperative Period Prospective Studies Stress, Physiological - physiology Surgery Time Factors Tumor Necrosis Factor-alpha - blood Urologic Surgical Procedures, Male - instrumentation Varicocele - blood Varicocele - diagnosis Varicocele - surgery |
| title | Early post-operative interleukin-6 and tumor necrosis factor-α levels after single-port laparoscopic varicocelectomy in children |
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