Routine blood tests to predict liver fibrosis in chronic hepatitis C

• Published in: World journal of gastroenterology : WJG 2012-02, Vol.18 (8), p.746-753
• Main Authors: Hsieh, Yung-Yu, Tung, Shui-Yi, Lee, Kamfai, Wu, Cheng-Shyong, Wei, Kuo-Liang, Shen, Chien-Heng, Chang, Te-Sheng, Lin, Yi-Hsiung
• Format: Article
• Language: English
• Subjects: Adult; Aged; Cohort Studies; Female; Hematologic Tests - methods; Hepatitis C, Chronic - blood; Hepatitis C, Chronic - pathology; Humans; Liver Cirrhosis - blood; Liver Cirrhosis - pathology; Male; Middle Aged; Original; Predictive Value of Tests; Retrospective Studies; ROC Curve; Sensitivity and Specificity; Severity of Illness Index; Young Adult; 丙型肝炎; 天冬氨酸转氨酶; 慢性; 纤维蛋白原; 肝纤维化; 血液检查; 谷丙转氨酶; 预测
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v18.i8.746

AIM： To verify the usefulness of FibroQ for predicting fi brosis in patients with chronic hepatitis C, compared with other noninvasive tests. METHODS： This retrospective cohort study included 237 consecutive patients with chronic hepatitis C who had undergone percutaneous liver biopsy before treatment. FibroQ, aspartate aminotransferase （AST）/alanine aminotransferase ratio （AAR）, AST to platelet ratioindex, cirrhosis discriminant score, age-platelet index （API）, Pohl score, FIB-4 index, and Lok＇s model were calculated and compared. RESULTS： FibroQ, FIB-4, AAR, API and Lok＇s model results increased significantly as fibrosis advanced （analysis of variance test： P 〈 0.001）. FibroQ trended to be superior in predicting signifi cant fi brosis score in chronic hepatitis C compared with other noninvasive tests. CONCLUSION： FibroQ is a simple and useful test for predicting signifi cant fi brosis in patients with chronic hepatitis C.