Transfusion-related acute lung injury: incidence and risk factors

• Published in: Blood 2012-02, Vol.119 (7), p.1757-1767
• Main Authors: Toy, Pearl, Gajic, Ognjen, Bacchetti, Peter, Looney, Mark R., Gropper, Michael A., Hubmayr, Rolf, Lowell, Clifford A., Norris, Philip J., Murphy, Edward L., Weiskopf, Richard B., Wilson, Gregory, Koenigsberg, Monique, Lee, Deanna, Schuller, Randy, Wu, Ping, Grimes, Barbara, Gandhi, Manish J., Winters, Jeffrey L., Mair, David, Hirschler, Nora, Sanchez Rosen, Rosa, Matthay, Michael A.
• Format: Article
• Language: English
• Subjects: Academic Medical Centers - statistics & numerical data; Acute Lung Injury - epidemiology; Acute Lung Injury - etiology; Adult; Aged; Biological and medical sciences; Blood Transfusion - statistics & numerical data; Case-Control Studies; Clinical Trials and Observations; Female; Hematologic and hematopoietic diseases; Humans; Incidence; Male; Medical sciences; Middle Aged; Population Surveillance; Retrospective Studies; Risk Factors; Transfusion Medicine; Transfusion Reaction; Young Adult
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood-2011-08-370932

Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality. To determine TRALI incidence by prospective, active surveillance and to identify risk factors by a case-control study, 2 academic medical centers enrolled 89 cases and 164 transfused controls. Recipient risk factors identified by multivariate analysis were higher IL-8 levels, liver surgery, chronic alcohol abuse, shock, higher peak airway pressure while being mechanically ventilated, current smoking, and positive fluid balance. Transfusion risk factors were receipt of plasma or whole blood from female donors (odds ratio = 4.5, 95% confidence interval [CI], 1.85-11.2, P = .001), volume of HLA class II antibody with normalized background ratio more than 27.5 (OR = 1.92/100 mL, 95% CI, 1.08-3.4, P = .03), and volume of anti–human neutrophil antigen positive by granulocyte immunofluoresence test (OR = 1.71/100 mL, 95% CI, 1.18-2.5, P = .004). Little or no risk was associated with older red blood cell units, noncognate or weak cognate class II antibody, or class I antibody. Reduced transfusion of plasma from female donors was concurrent with reduced TRALI incidence: 2.57 (95% CI, 1.72-3.86) in 2006 versus 0.81 (95% CI, 0.44-1.49) in 2009 per 10 000 transfused units (P = .002). The identified risk factors provide potential targets for reducing residual TRALI.