Adiponectin-AdipoR1/2-APPL1 signaling axis suppresses human foam cell formation: Differential ability of AdipoR1 and AdipoR2 to regulate inflammatory cytokine responses

• Published in: Atherosclerosis 2012-03, Vol.221 (1), p.66-75
• Main Authors: Tian, Ling, Luo, Nanlan, Zhu, Xiaolin, Chung, Byung-Hong, Garvey, W. Timothy, Fu, Yuchang
• Format: Article
• Language: English
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Adiponectin; Adiponectin - metabolism; Adiponectin receptor; adiponectin receptors; antagonists; APPL1; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Atherosclerosis - genetics; Atherosclerosis - immunology; Atherosclerosis - metabolism; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular; Carrier Proteins - metabolism; Cell Line, Tumor; chemokines; Cholesterol - metabolism; Cytokines - genetics; Cytokines - metabolism; Diseases of the cardiovascular system; Foam cells; Foam Cells - immunology; Foam Cells - metabolism; foaming; gene expression; Gene Expression Regulation; genes; Humans; Inflammation; Inflammation - genetics; Inflammation - immunology; Inflammation - metabolism; Inflammation Mediators - metabolism; interleukin-1; leucine zipper; Lipoproteins, LDL - metabolism; low density lipoprotein; Macrophages; Medical sciences; monocytes; NF-kappa B - metabolism; Phosphorylation; Proto-Oncogene Proteins c-akt - metabolism; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Receptors, Adiponectin - genetics; Receptors, Adiponectin - metabolism; RNA Interference; RNA, Messenger - metabolism; Signal Transduction; transcription factor NF-kappa B; Transfection; tumor necrosis factor-alpha
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2011.12.014

Highlights ► Adiponectin suppresses foam cell transformation through AdipoR1, AdipoR2 and APPL1. ► AdipoR1 is required by adiponectin to suppress TNFα and MCP-1 gene expression. ► AdipoR2 is the dominant receptor to suppress SR-AI and upregulate IL-1Ra. ► APPL1 is required to inhibit SR-AI and NF-κB gene expression and Akt phosphorylation.