Consistency of HLA associations between two independent measles vaccine cohorts: A replication study

Highlights ► Two independent study cohorts of healthy school children were examined. ► Purpose of study to identify associations between HLA genes and immune responses. ► Purpose of study to replicate associations between HLA genes and immune responses. ► First HLA association replication study with...

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Bibliographic Details
Published in:Vaccine 2012-03, Vol.30 (12), p.2146-2152
Main Authors: Ovsyannikova, Inna G, Shane Pankratz, V, Vierkant, Robert A, Jacobson, Robert M, Poland, Gregory A
Format: Article
Language:English
Subjects:
Adolescent
Age
alleles
Allergy and Immunology
Antibodies
Antibodies, Viral - blood
B7 antigen
cell-mediated immunity
Child
Children
Cohort Studies
Confidence intervals
Cytokines
Data processing
Enzymes
Female
gamma -Interferon
genotype
Genotypes
Haplotypes
Histocompatibility antigen HLA
HLA Antigens - genetics
HLA genotypes
Humans
Immune response
Immune response (humoral)
Immune system
Immunogenetics
Independent study
interferon-gamma
Interleukin 10
Interleukin 2
Male
Measles
Measles - immunology
Measles - prevention & control
Measles vaccine
Measles Vaccine - administration & dosage
Measles Vaccine - immunology
Regression analysis
Replication
Replication study
school children
secretion
Statistical methods
Studies
vaccination
vaccine development
Vaccines
Young Adult
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Description
Summary:Highlights ► Two independent study cohorts of healthy school children were examined. ► Purpose of study to identify associations between HLA genes and immune responses. ► Purpose of study to replicate associations between HLA genes and immune responses. ► First HLA association replication study with measles vaccine-specific immune responses to date.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.01.038