Patterns of body fat deposition in youth and their relation to left ventricular markers of adverse cardiovascular prognosis

The patterns of body fat deposition in healthy youth and their relation to future development of cardiovascular disease remain incompletely understood. To further evaluate these patterns, we measured indirect indexes of central and general fat deposition in healthy adolescents (mean age 15.4 ± 2.3 y...

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Bibliographic Details
Published in:The American journal of cardiology 1999-09, Vol.84 (5), p.583-588
Main Authors: Mensah, George A, Treiber, Frank A, Kapuku, Gaston K, Davis, Harry, Barnes, Vernon A, Strong, William B
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anthropometry
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Body Composition - physiology
Body fat
Body Mass Index
Cardiac Volume - physiology
Cardiology
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Echocardiography
Female
Genetic Predisposition to Disease - genetics
Heart
Hemodynamics - physiology
Humans
Hypertension - genetics
Hypertension - physiopathology
Hypertrophy, Left Ventricular - genetics
Hypertrophy, Left Ventricular - physiopathology
Longitudinal Studies
Male
Medical sciences
Morbidity
Obesity - genetics
Obesity - physiopathology
Prognosis
Risk Factors
Skinfold Thickness
Somatotypes - physiology
Teenagers
Ventricular Remodeling - physiology
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Summary:The patterns of body fat deposition in healthy youth and their relation to future development of cardiovascular disease remain incompletely understood. To further evaluate these patterns, we measured indirect indexes of central and general fat deposition in healthy adolescents (mean age 15.4 ± 2.3 years) with family histories of hypertension. We examined the relation between these indexes and echocardiographic markers of adverse prognosis as well as the effect of gender and ethnicity. All 225 subjects (64% black and 48% female) had ≥1 biologic parent and 1 grandparent with hypertension. Skinfold thicknesses, waist-to-hip girth ratio, Quetelet index, Ponderal index, conicity, and Z score weight − Z score height were measured. Left ventricular (LV) mass, indexed LV mass, relative wall thickness (RWT), and midwall fractional shortening (MFS) were determined using echocardiography. In both black and white subjects, the adiposity indexes were significantly correlated with posterior wall thickness, total LV mass, and indexed LV mass (p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(99)00383-5