The application of cold-plasma coagulation on the visceral pleura results in a predictable depth of necrosis without fistula generation

A technique for the safe transfer of electric energy to the pulmonary surface for the potential evaporation of malignant tumours is non-existent to date. By conducting the current study, we wanted to generate data on the potential beneficiary effects and complications of using cold-plasma coagulatio...

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Published in:Interactive cardiovascular and thoracic surgery 2012-03, Vol.14 (3), p.239-243
Main Authors: Hoffmann, Martin, Ulrich, Anita, Schloericke, Erik, Limmer, Stefan, Habermann, Jens Karsten, Wolken, Heike, Bruch, Hans-Peter, Kujath, Peter
Format: Article
Language:English
Subjects:
Animals
Argon Plasma Coagulation - instrumentation
Disease Models, Animal
Equipment Design
Female
Follow-Up Studies
Institutional Report
Lung - pathology
Lung Diseases - etiology
Lung Diseases - pathology
Lung Diseases - prevention & control
Mesothelioma - pathology
Mesothelioma - surgery
Necrosis - complications
Necrosis - pathology
Pleura - pathology
Pleura - surgery
Pleural Neoplasms - pathology
Pleural Neoplasms - surgery
Respiratory Tract Fistula - etiology
Respiratory Tract Fistula - pathology
Respiratory Tract Fistula - prevention & control
Swine
Swine, Miniature
Thoracoscopy
Treatment Outcome
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Summary:A technique for the safe transfer of electric energy to the pulmonary surface for the potential evaporation of malignant tumours is non-existent to date. By conducting the current study, we wanted to generate data on the potential beneficiary effects and complications of using cold-plasma coagulation on the pulmonary surface. Cold-plasma coagulation was applied to the pulmonary surface in eight female mini-pigs via a thoracoscopic access. After 12 days, we performed a re-thoracoscopy on the contralateral side. After a further 12 days, we performed a median sternotomy and did cold-plasma coagulation on previously untreated areas of either lung. No pulmonary fistulas were detected. In two of the eight pigs, we found a localized chronic pneumonia. None of the pigs died during the course of the study. Morbidity was also low with two pigs refusing food intake, one pig with dyspnoea after difficult intubation and one pig coughing. All events were self-limited and occurred only on post-operative Day 1. The treatment effect was almost linear and correlated to the generator energy applied. The differences between the effects reached statistical significance (P 
ISSN:1569-9293
1569-9285
DOI:10.1093/icvts/ivr109