Acute oral toxicity evaluations of some zinc(II) complexes derived from 1-(2-salicylaldiminoethyl)piperazine Schiff bases in rats

• Published in: International journal of molecular sciences 2012-02, Vol.13 (2), p.1393-1404
• Main Authors: Salga, Muhammad Saleh, Ali, Hapipah Mohd, Abdulla, Mahmood Ameen, Abdelwahab, Siddig Ibrahim
• Format: Article
• Language: English
• Subjects: Administration, Oral; Alanine Transaminase - blood; Alkaline Phosphatase - blood; Animals; Aspartic Acid - blood; C-Reactive Protein - metabolism; Dose-Response Relationship, Drug; Erythrocyte Indices; Female; Immunoglobulins - blood; Inorganic chemistry; Ligands; Lipoproteins, HDL - blood; Male; Phenols; Piperazines - toxicity; Rats; Rats, Sprague-Dawley; Schiff Bases - toxicity; Time Factors; Toxicity; Triglycerides - blood; Zinc; Zinc - toxicity
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms13021393

The current study described the synthesis and the in vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds were characterized by elemental analyses, LC-MS, FTIR, (1)H NMR, (13)C NMR and UV-visible spectroscopy. In the acute toxicity study, a single administration of the compounds was performed orally to the rats at the single doses of 2000 mg/kg and they were then monitored for possible side effects, mortality or behavioral changes up to 14 days. The serum level of aspartate (AST), alanine aminotransferases (ALT), alkaline phosphate (ALP), triglyceride, high density lipoprotein (HDL), immunoglobulins (GAM) and the C-reactive proteins did not significantly change. The hematological indices white blood cells (WBC), haematocrit (HCT), red blood cells (RBC), mean corpuscular volume (MCV), mean corpuscular haemoglobin concentration (MCHC), and mean corpuscular hemoglobin (MCH) were within the normal range. The renal function indices examined were also within the reference range. Generally, the compounds exhibited low toxic effects as required for further in vivo therapeutic studies.