Lipid peroxidative damage on Cisplatin exposure and alterations in antioxidant defense system in rat kidneys: a possible protective effect of selenium

Cisplatin (Cis-diamminedichloroplatinum II, CP) is an important chemotherapeutic agent, useful in the treatment of several cancers, but with several side effects such as nephrotoxicity. The present study investigated the possible protective effect of selenium (Se) against CP-induced oxidative stress...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2012-02, Vol.13 (2), p.1790-1803
Main Authors: Ognjanović, Branka I, Djordjević, Nataša Z, Matić, Miloš M, Obradović, Jasmina M, Mladenović, Jelena M, Stajn, Andraš Š, Saičić, Zorica S
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - adverse effects
Antioxidants
Antioxidants - metabolism
Cardiovascular disease
Catalase - metabolism
Cisplatin - adverse effects
Cytoprotection - drug effects
Defense
Enzymes
Glutathione Peroxidase - metabolism
Glutathione Reductase - metabolism
Kidney - drug effects
Kidney - metabolism
Kidneys
Lipid peroxidation
Lipid Peroxidation - drug effects
Lipids
Male
Oxidative stress
Oxidative Stress - drug effects
Protein synthesis
Rats
Rats, Wistar
Selenium
Selenium - pharmacology
Superoxide Dismutase - metabolism
Toxicity
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cisplatin (Cis-diamminedichloroplatinum II, CP) is an important chemotherapeutic agent, useful in the treatment of several cancers, but with several side effects such as nephrotoxicity. The present study investigated the possible protective effect of selenium (Se) against CP-induced oxidative stress in the rat kidneys. Male Wistar albino rats were injected with a single dose of cisplatin (7 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na(2)SeO(3), i.p.), alone or in combination. The obtained results showed that CP increased lipid peroxidation (LPO) and decreased reduced glutathione (GSH) concentrations, suggesting the CP-induced oxidative stress, while Se treatment reversed this change to control values. Acute intoxication of rats with CP was followed by statistically significant decreased activity of antioxidant defense enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST). Treatment with Se reversed CP-induced alterations of antioxidant defense enzyme activities and significantly prevented the CP-induced kidney damage.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms13021790