Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes

We analyzed the antimycobacterial activity of the hexane extract of rhizomes from Aristolochia elegans. Some compounds of this extract were purified and tested against a group of drug-resistant Mycobacterium tuberculosis strains. We also evaluated their antiprotozoal activities. The hexane extract w...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2012-01, Vol.2012 (2012), p.1-7
Main Authors: Yépez-Mulia, Lilián, Molina-Salinas, Gloria María, Tapia, Amparo, Meckes, Mariana, León-Díaz, Rosalba, Jiménez-Arellanes, Adelina, Luna-Herrera, Julieta
Format: Article
Language:English
Subjects:
Aristolochia
Aristolochia elegans
Chromatography
Drug resistance
Herbal medicine
Infectious diseases
Minimum inhibitory concentration
Natural products
Rhizomes
Seeds
Tuberculosis
Venom
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Summary:We analyzed the antimycobacterial activity of the hexane extract of rhizomes from Aristolochia elegans. Some compounds of this extract were purified and tested against a group of drug-resistant Mycobacterium tuberculosis strains. We also evaluated their antiprotozoal activities. The hexane extract was active against M. tuberculosis H37Rv at a MIC=100 μg mL−1; the pure compounds eupomatenoid-1, fargesin, and (8R,8′R,9R)-cubebin were active against M. tuberculosis H37Rv (MIC = 50 μg mL−1), while fargesin presented activity against three monoresistant strains of M. tuberculosis H37Rv and a MDR clinical isolate of M. tuberculosis (MIC
ISSN:1741-427X
1741-4288
DOI:10.1155/2012/593403