The immunology of fibrosis: innate and adaptive responses

Fibrosis is an important health problem, and its pathogenetic principles are still largely unknown. It can develop either spontaneously, or, more frequently, as a consequence of various underlying diseases. Irrespective of the primary cause, however, fibrotic tissue is always infiltrated by mononucl...

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Published in:Trends in immunology 2010-03, Vol.31 (3), p.110-119
Main Authors: Wick, Georg, Backovic, Aleksandar, Rabensteiner, Evelyn, Plank, Nadine, Schwentner, Christian, Sgonc, Roswitha
Format: Article
Language:English
Subjects:
Adaptive Immunity - immunology
Allergy and Immunology
Animals
Apolipoproteins
Cell cycle
Chemokines
Cytokines
Dehydrogenases
Disease
Enzymes
Fibroblasts - cytology
Fibroblasts - immunology
Fibroblasts - metabolism
Fibrosis - etiology
Fibrosis - immunology
Fibrosis - metabolism
Fibrosis - therapy
Humans
Immune system
Immunity, Innate - immunology
Lymphocytes
Proteins
Rodents
T cell receptors
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Summary:Fibrosis is an important health problem, and its pathogenetic principles are still largely unknown. It can develop either spontaneously, or, more frequently, as a consequence of various underlying diseases. Irrespective of the primary cause, however, fibrotic tissue is always infiltrated by mononuclear immune cells. In most instances the reason for the attraction of these cells to fibrotic tissue and their proliferation remains to be determined; however their cytokine profile shows clear-cut proinflammatory and profibrotic characteristics. In this review, we discuss the innate and adaptive immune reactions associated with the development of fibrosis and the molecular basis of the profibrotic mechanisms taking place in systemic sclerosis (scleroderma), arteriosclerosis and peri-silicone mammary implant fibrosis.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2009.12.001