ABCB1 Genotype and CSF β-Amyloid in Alzheimer Disease

The ABCB1 gene, coding for the efflux transporter P-glycoprotein (PGP), is a candidate gene for Alzheimer disease (AD). P-glycoprotein is heavily expressed at the blood—brain barrier, where it mediates the efflux of β-amyloid (Aβ) from the brain. In this study, we investigated a possible association...

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Bibliographic Details
Published in:Journal of geriatric psychiatry and neurology 2011-06, Vol.24 (2), p.63-66
Main Authors: Kohen, R., Shofer, J.B., Korvatska, O., Petrie, E.C., Wang, L.Y., Schellenberg, G.D., Peskind, E.R., Wilkinson, C.W.
Format: Article
Language:English
Subjects:
Aged
Alleles
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - genetics
Amyloid beta-Peptides - cerebrospinal fluid
ATP Binding Cassette Transporter, Sub-Family B
ATP-Binding Cassette, Sub-Family B, Member 1 - genetics
Female
Gene Frequency
Genetic Association Studies
Humans
Linear Models
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
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Summary:The ABCB1 gene, coding for the efflux transporter P-glycoprotein (PGP), is a candidate gene for Alzheimer disease (AD). P-glycoprotein is heavily expressed at the blood—brain barrier, where it mediates the efflux of β-amyloid (Aβ) from the brain. In this study, we investigated a possible association between 2 common ABCB1 polymorphisms, G2677T/A (Ala893Ser/Thr) and C3435T, AD, and cerebrospinal fluid (CSF) levels of Aβ. No strong evidence for association was found.
ISSN:0891-9887
1552-5708
0891-9887
DOI:10.1177/0891988711402325