Nitrogen Monoxide (NO) Storage and Transport by Dinitrosyl-Dithiol-Iron Complexes: Long-lived NO That Is Trafficked by Interacting Proteins

Nitrogen monoxide (NO) markedly affects intracellular iron metabolism, and recent studies have shown that molecules traditionally involved in drug resistance, namely GST and MRP1 (multidrug resistance-associated protein 1), are critical molecular players in this process. This is mediated by interact...

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Bibliographic Details
Published in:The Journal of biological chemistry 2012-03, Vol.287 (10), p.6960-6968
Main Authors: Suryo Rahmanto, Yohan, Kalinowski, Danuta S., Lane, Darius J.R., Lok, Hiu Chuen, Richardson, Vera, Richardson, Des R.
Format: Article
Language:English
Subjects:
Animals
Biological Transport, Active - physiology
Glutathione - metabolism
Glutathione S-Transferase pi - metabolism
Humans
Iron
Iron Compounds - metabolism
Iron Metabolism
Metals
Minireviews
Multidrug Resistance-Associated Proteins - metabolism
Nitric Oxide - metabolism
Nitrogen Oxides - metabolism
Protein-Metal Ion Interaction
Signal Transduction - physiology
Transport Metals
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Summary:Nitrogen monoxide (NO) markedly affects intracellular iron metabolism, and recent studies have shown that molecules traditionally involved in drug resistance, namely GST and MRP1 (multidrug resistance-associated protein 1), are critical molecular players in this process. This is mediated by interaction of these proteins with dinitrosyl-dithiol-iron complexes (Watts, R. N., Hawkins, C., Ponka, P., and Richardson, D. R. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 7670–7675; Lok, H. C., Suryo Rahmanto, Y., Hawkins, C. L., Kalinowski, D. S., Morrow, C. S., Townsend, A. J., Ponka, P., and Richardson, D. R. (2012) J. Biol. Chem. 287, 607–618). These complexes are bioavailable, have a markedly longer half-life compared with free NO, and form in cells after an interaction between iron, NO, and glutathione. The generation of dinitrosyl-dithiol-iron complexes acts as a common currency for NO transport and storage by MRP1 and GST P1-1, respectively. Understanding the biological trafficking mechanisms involved in the metabolism of NO is vital for elucidating its many roles in cellular signaling and cytotoxicity and for development of new therapeutic targets.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.R111.329847