Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release

Mesoporous silica nanoparticles (MSNPs) have garnered a great deal of attention as potential carriers for therapeutic payloads. However, achieving triggered drug release from MSNPs in vivo has been challenging. Here, we describe the synthesis of stimulus-responsive polymer-coated MSNPs and the loadi...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2011-12, Vol.133 (49), p.19582-19585
Main Authors: Singh, Neetu, Karambelkar, Amrita, Gu, Luo, Lin, Kevin, Miller, Jordan S, Chen, Christopher S, Sailor, Michael J, Bhatia, Sangeeta N
Format: Article
Language:English
Subjects:
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - pharmacology
Cell Survival - drug effects
Communication
Delayed-Action Preparations - chemistry
Delayed-Action Preparations - metabolism
Doxorubicin - administration & dosage
Doxorubicin - pharmacology
HeLa Cells
Humans
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Neoplasms - drug therapy
Peptide Hydrolases - metabolism
Polymers - chemistry
Polymers - metabolism
Porosity
Silicon Dioxide - chemistry
Silicon Dioxide - metabolism
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Summary:Mesoporous silica nanoparticles (MSNPs) have garnered a great deal of attention as potential carriers for therapeutic payloads. However, achieving triggered drug release from MSNPs in vivo has been challenging. Here, we describe the synthesis of stimulus-responsive polymer-coated MSNPs and the loading of therapeutics into both the core and shell domains. We characterize MSNP drug-eluting properties in vitro and demonstrate that the polymer-coated MSNPs release doxorubicin in response to proteases present at a tumor site in vivo, resulting in cellular apoptosis. These results demonstrate the utility of polymer-coated nanoparticles in specifically delivering an antitumor payload.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja206998x