Vitamin e supplementation with rauwolfia vomitoria root bark extract improves hematological indices

• Published in: North American journal of medical sciences 2012-02, Vol.4 (2), p.86-89
• Main Authors: Isaiah, Akpanabiatu Monday, Olawale, Otitoju, Effiong, Edet Emmanuel, Idongesit, Ndem Jessie, Fidelis, Uwah Anthony, Friday, Ufot Usenobong
• Format: Article
• Language: English
• Subjects: Dosage and administration; Health aspects; Hematopoietic system; Herb-drug interactions; Original; Physiological aspects; Rauwolfia; Vitamin E
• ISSN: 1947-2714; 2250-1541; 1947-2714
• DOI: 10.4103/1947-2714.93383

Vitamin supplementation in Rauwolfia vomitoria root bark extract administration may interact and impact significantly on hematology of albino Wistar rats. In this investigation we studied vitamin E supplementation with Rauwolfia vomitoria root bark extract on the hematology of experimental animals. Forty two rats weighing 200 - 230 g were randomly selected into six groups of seven animals each. Group 1 animals serve as controls; group 2 received vitamin E (10 IU/kg body weight). Groups 3 and 4 were given the extract (150 and 300 mg/kg body weight) respectively. Groups 5 and 6 were given vitamin E (10 IU/kg body weight), the extract (150 and 300 mg/kg body weight) respectively. The extract and the vitamin were administered daily by oral intubation. Blood samples analyzed for hematological indices. Decrease in white blood cell count (WBC) was observed, indicating improved immunity of animals. Extract at 150 and 300 mg/kg body weight with and without vitamin E affected hemoglobin and packed cell volume. Rauwolfia vomitoria with or without vitamin E improved animal's immunity and enhances their hematology. Interaction of vitamin E with the extract affects medicinal therapeutics of this plant.