Voxel-wise meta-analysis of fMRI studies in patients at clinical high risk for psychosis

Background Reliable neurofunctional markers of increased vulnerability to psychosis are needed to improve the predictive value of psychosis risk syndrome and inform preventive interventions. Methods I performed a signed differential mapping (SDM) voxel-wise meta-analysis of functional magnetic reson...

Full description

Saved in:
Bibliographic Details
Published in:Journal of psychiatry & neuroscience 2012-03, Vol.37 (2), p.106-112
Main Author: Fusar-Poli, Paolo, MD, PhD
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brain
Female
Fundamental and applied biological sciences. Psychology
Health risk assessment
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical Education
Medical sciences
Meta-analysis
Methods
NMR
Nuclear magnetic resonance
Physiological aspects
Predictive Value of Tests
Psychiatry
Psychoanalysis
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopathology. Psychiatry
Psychoses
Psychosis
Psychotic Disorders - pathology
Publication Bias
Research Papers
Risk Assessment
Risk factors
Sample Size
Schizophrenia
Sex Factors
Socioeconomic Factors
Systematic review
Young Adult
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Reliable neurofunctional markers of increased vulnerability to psychosis are needed to improve the predictive value of psychosis risk syndrome and inform preventive interventions. Methods I performed a signed differential mapping (SDM) voxel-wise meta-analysis of functional magnetic resonance imaging (fMRI) studies of patients at clinical high risk for psychosis. Results Ten studies were included in the analysis. Compared with controls, high-risk patients showed reduced neural activation in the left inferior frontal gyrus (Brodmann area [BA] 9) and in a cluster spanning the bilateral medial frontal gyrus (BA 8,6), bilateral superior frontal gyrus (BA 8,6) and the left anterior cingulate (BA 32). There was no publication bias. Heterogeneity across studies was low. Sensitivity analysis confirmed the robustness of the findings. Limitations The cross-sectional nature of the included studies prevented the comparison of high-risk patients who later experienced a psychotic episode with those who did not. Other caveats are reflected in methodologic heterogeneity across tasks employed by different individual imaging studies. Conclusion Reduced neurofunctional activation in prefrontal regions may represent a neurophysiologic correlate of increased vulnerability to psychosis.
ISSN:1180-4882
1488-2434
DOI:10.1503/jpn.110021