Tuberculin Skin Test Reactivity Is Dependent on Host Genetic Background in Colombian Tuberculosis Household Contacts

The tuberculin skin test (TST) measures the intensity of antimycobacterial acquired immunity and is used to diagnose latent infection with Mycobacterium tuberculosis. We report evidence for a codominant gene explaining ~65% of the TST variability. Disregarding the host genetic background may lead to...

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Bibliographic Details
Published in:Clinical infectious diseases 2012-04, Vol.54 (7), p.968-971
Main Authors: Cobat, Aurélie, Barrera, Luis F., Henao, Hanna, Arbeláez, Patricia, Abel, Laurent, García, Luis F., Schurr, Erwin, Alcaïs, Alexandre
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Bacterial diseases
Beds
Biological and medical sciences
BRIEF REPORTS
Child
Child, Preschool
Classification
Colombia
Family Characteristics
Female
Genetic Variation
Genetics
Gram-positive bacteria
Human bacterial diseases
Human genetics
Humans
Infant
Infectious diseases
Latent Tuberculosis - diagnosis
Latent Tuberculosis - genetics
Latent Tuberculosis - immunology
Male
Measurement techniques
Medical diagnosis
Medical genetics
Medical sciences
Middle Aged
Modeling
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Reactivity
Scars
Skin tests
Tuberculin
Tuberculin Test - methods
Tuberculosis
Tuberculosis and atypical mycobacterial infections
Tuberculosis vaccine
Young Adult
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Description
Summary:The tuberculin skin test (TST) measures the intensity of antimycobacterial acquired immunity and is used to diagnose latent infection with Mycobacterium tuberculosis. We report evidence for a codominant gene explaining ~65% of the TST variability. Disregarding the host genetic background may lead to misclassifications of TST-based diagnosis of latent M. tuberculosis infection.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cir972