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Genetic Susceptibility to Type 2 Diabetes and Breast Cancer Risk in Women of European and African Ancestry
Epidemiologic studies have reported a positive association between type 2 diabetes (T2D) and breast cancer risk, independent of body weight. We investigated 40 genetic variants known to be associated with T2D in relation to breast cancer risk among 2,651 breast cancer cases and 2,520 controls of Afr...
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| Published in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2012-03, Vol.21 (3), p.552-556 |
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| container_title | Cancer epidemiology, biomarkers & prevention |
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| creator | NINGQI HOU YONGLAN ZHENG HENNIS, Anselm NEMESURE, Barbara WU, Suh-Yuh CRISTINA LESKE, M AMBS, Stefan QUN NIU JING ZHANG PIERCE, Brandon COX, Nancy J OLOPADE, Olufunmilayo I GAMAZON, Eric R DEZHENG HUO OGUNDIRAN, Temidayo O ADEBAMOWO, Clement NATHANSON, Katherine L DOMCHEK, Susan M REBBECK, Timothy R SIMON, Michael S JOHN, Esther M |
| description | Epidemiologic studies have reported a positive association between type 2 diabetes (T2D) and breast cancer risk, independent of body weight.
We investigated 40 genetic variants known to be associated with T2D in relation to breast cancer risk among 2,651 breast cancer cases and 2,520 controls of African or European ancestry that were pooled from seven studies.
We found that two T2D risk alleles in Caucasian women (rs5945326-G, rs12518099-C) and one in women of African ancestry (rs7578597-T) were positively associated with breast cancer risk at a nominal significance level of 0.05, whereas two T2D risk alleles were inversely associated with breast cancer risk in Caucasian women (rs1111875-C, rs10923931-T). The composite T2D susceptibility score (the number of risk allele) was not significantly associated with breast cancer risk.
The association between established T2D genetic susceptibility variants and breast cancer risk in women of African or European ancestry is likely weak, if it does exist.
The pleiotropic effects of known T2D risk alleles cannot explain the association between T2D and breast cancer risk. |
| doi_str_mv | 10.1158/1055-9965.EPI-11-0979 |
| format | article |
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We investigated 40 genetic variants known to be associated with T2D in relation to breast cancer risk among 2,651 breast cancer cases and 2,520 controls of African or European ancestry that were pooled from seven studies.
We found that two T2D risk alleles in Caucasian women (rs5945326-G, rs12518099-C) and one in women of African ancestry (rs7578597-T) were positively associated with breast cancer risk at a nominal significance level of 0.05, whereas two T2D risk alleles were inversely associated with breast cancer risk in Caucasian women (rs1111875-C, rs10923931-T). The composite T2D susceptibility score (the number of risk allele) was not significantly associated with breast cancer risk.
The association between established T2D genetic susceptibility variants and breast cancer risk in women of African or European ancestry is likely weak, if it does exist.
The pleiotropic effects of known T2D risk alleles cannot explain the association between T2D and breast cancer risk.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-11-0979</identifier><identifier>PMID: 22237986</identifier><identifier>CODEN: CEBPE4</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; African Continental Ancestry Group - statistics & numerical data ; Bioindicators ; Biological and medical sciences ; Body weight ; Breast cancer ; Breast Neoplasms - ethnology ; Breast Neoplasms - etiology ; Cancer ; Case-Control Studies ; Composite materials ; Diabetes Complications - ethnology ; Diabetes Complications - etiology ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; European Continental Ancestry Group - statistics & numerical data ; Female ; Females ; Follow-Up Studies ; Genetic Predisposition to Disease ; Humans ; Medical sciences ; Middle Aged ; Prevention ; Prognosis ; Risk Factors ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2012-03, Vol.21 (3), p.552-556</ispartof><rights>2015 INIST-CNRS</rights><rights>2012 AACR.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-82081e1f9738b1ec419828ea86a366f02681c1da095e529995e9ca29f67658033</citedby><cites>FETCH-LOGICAL-c473t-82081e1f9738b1ec419828ea86a366f02681c1da095e529995e9ca29f67658033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25785147$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22237986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NINGQI HOU</creatorcontrib><creatorcontrib>YONGLAN ZHENG</creatorcontrib><creatorcontrib>HENNIS, Anselm</creatorcontrib><creatorcontrib>NEMESURE, Barbara</creatorcontrib><creatorcontrib>WU, Suh-Yuh</creatorcontrib><creatorcontrib>CRISTINA LESKE, M</creatorcontrib><creatorcontrib>AMBS, Stefan</creatorcontrib><creatorcontrib>QUN NIU</creatorcontrib><creatorcontrib>JING ZHANG</creatorcontrib><creatorcontrib>PIERCE, Brandon</creatorcontrib><creatorcontrib>COX, Nancy J</creatorcontrib><creatorcontrib>OLOPADE, Olufunmilayo I</creatorcontrib><creatorcontrib>GAMAZON, Eric R</creatorcontrib><creatorcontrib>DEZHENG HUO</creatorcontrib><creatorcontrib>OGUNDIRAN, Temidayo O</creatorcontrib><creatorcontrib>ADEBAMOWO, Clement</creatorcontrib><creatorcontrib>NATHANSON, Katherine L</creatorcontrib><creatorcontrib>DOMCHEK, Susan M</creatorcontrib><creatorcontrib>REBBECK, Timothy R</creatorcontrib><creatorcontrib>SIMON, Michael S</creatorcontrib><creatorcontrib>JOHN, Esther M</creatorcontrib><title>Genetic Susceptibility to Type 2 Diabetes and Breast Cancer Risk in Women of European and African Ancestry</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Epidemiologic studies have reported a positive association between type 2 diabetes (T2D) and breast cancer risk, independent of body weight.
We investigated 40 genetic variants known to be associated with T2D in relation to breast cancer risk among 2,651 breast cancer cases and 2,520 controls of African or European ancestry that were pooled from seven studies.
We found that two T2D risk alleles in Caucasian women (rs5945326-G, rs12518099-C) and one in women of African ancestry (rs7578597-T) were positively associated with breast cancer risk at a nominal significance level of 0.05, whereas two T2D risk alleles were inversely associated with breast cancer risk in Caucasian women (rs1111875-C, rs10923931-T). The composite T2D susceptibility score (the number of risk allele) was not significantly associated with breast cancer risk.
The association between established T2D genetic susceptibility variants and breast cancer risk in women of African or European ancestry is likely weak, if it does exist.
The pleiotropic effects of known T2D risk alleles cannot explain the association between T2D and breast cancer risk.</description><subject>Adult</subject><subject>African Continental Ancestry Group - statistics & numerical data</subject><subject>Bioindicators</subject><subject>Biological and medical sciences</subject><subject>Body weight</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - ethnology</subject><subject>Breast Neoplasms - etiology</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Composite materials</subject><subject>Diabetes Complications - ethnology</subject><subject>Diabetes Complications - etiology</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>European Continental Ancestry Group - statistics & numerical data</subject><subject>Female</subject><subject>Females</subject><subject>Follow-Up Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prevention</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Tumors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kUtvEzEQgC1ERUvhJ4B8QXDZ1o_4dUEKIZRKlUBQxNFynFlw2dhb24uUf49D05ZeOM3I_mY0Mx9CLyg5oVToU0qE6IyR4mT5-byjtCNGmUfoiAquO6WEeNzyW-YQPS3lihCijBBP0CFjjCuj5RG6OoMINXj8dSoexhpWYQh1i2vCl9sRMMPvg1tBhYJdXON3GVypeOGih4y_hPILh4i_pw1EnHq8nHIawcW_7LzPwbd83thS8_YZOujdUOD5Ph6jbx-Wl4uP3cWns_PF_KLzM8VrpxnRFGhvFNcrCn5GjWYanJaOS9kTJjX1dO2IESCYMS0Y75jppZJCE86P0dubvuO02sDaQ6zZDXbMYePy1iYX7MOfGH7aH-m35cwoaURr8HrfIKfrqc1uN6EdZxhchDQVa1jDCDOykW_-S1LCZ5pyIlRDxQ3qcyolQ383ECV2Z9TubNmdLduMtie7M9rqXv67zV3VrcIGvNoDrng39Lm5CeWeE0oL2i77B64TqQA</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>NINGQI HOU</creator><creator>YONGLAN ZHENG</creator><creator>HENNIS, Anselm</creator><creator>NEMESURE, Barbara</creator><creator>WU, Suh-Yuh</creator><creator>CRISTINA LESKE, M</creator><creator>AMBS, Stefan</creator><creator>QUN NIU</creator><creator>JING ZHANG</creator><creator>PIERCE, Brandon</creator><creator>COX, Nancy J</creator><creator>OLOPADE, Olufunmilayo I</creator><creator>GAMAZON, Eric R</creator><creator>DEZHENG HUO</creator><creator>OGUNDIRAN, Temidayo O</creator><creator>ADEBAMOWO, Clement</creator><creator>NATHANSON, Katherine L</creator><creator>DOMCHEK, Susan M</creator><creator>REBBECK, Timothy R</creator><creator>SIMON, Michael S</creator><creator>JOHN, Esther M</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120301</creationdate><title>Genetic Susceptibility to Type 2 Diabetes and Breast Cancer Risk in Women of European and African Ancestry</title><author>NINGQI HOU ; YONGLAN ZHENG ; HENNIS, Anselm ; NEMESURE, Barbara ; WU, Suh-Yuh ; CRISTINA LESKE, M ; AMBS, Stefan ; QUN NIU ; JING ZHANG ; PIERCE, Brandon ; COX, Nancy J ; OLOPADE, Olufunmilayo I ; GAMAZON, Eric R ; DEZHENG HUO ; OGUNDIRAN, Temidayo O ; ADEBAMOWO, Clement ; NATHANSON, Katherine L ; DOMCHEK, Susan M ; REBBECK, Timothy R ; SIMON, Michael S ; JOHN, Esther M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-82081e1f9738b1ec419828ea86a366f02681c1da095e529995e9ca29f67658033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>African Continental Ancestry Group - statistics & numerical data</topic><topic>Bioindicators</topic><topic>Biological and medical sciences</topic><topic>Body weight</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - ethnology</topic><topic>Breast Neoplasms - etiology</topic><topic>Cancer</topic><topic>Case-Control Studies</topic><topic>Composite materials</topic><topic>Diabetes Complications - ethnology</topic><topic>Diabetes Complications - etiology</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>European Continental Ancestry Group - statistics & numerical data</topic><topic>Female</topic><topic>Females</topic><topic>Follow-Up Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prevention</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NINGQI HOU</creatorcontrib><creatorcontrib>YONGLAN ZHENG</creatorcontrib><creatorcontrib>HENNIS, Anselm</creatorcontrib><creatorcontrib>NEMESURE, Barbara</creatorcontrib><creatorcontrib>WU, Suh-Yuh</creatorcontrib><creatorcontrib>CRISTINA LESKE, M</creatorcontrib><creatorcontrib>AMBS, Stefan</creatorcontrib><creatorcontrib>QUN NIU</creatorcontrib><creatorcontrib>JING ZHANG</creatorcontrib><creatorcontrib>PIERCE, Brandon</creatorcontrib><creatorcontrib>COX, Nancy J</creatorcontrib><creatorcontrib>OLOPADE, Olufunmilayo I</creatorcontrib><creatorcontrib>GAMAZON, Eric R</creatorcontrib><creatorcontrib>DEZHENG HUO</creatorcontrib><creatorcontrib>OGUNDIRAN, Temidayo O</creatorcontrib><creatorcontrib>ADEBAMOWO, Clement</creatorcontrib><creatorcontrib>NATHANSON, Katherine L</creatorcontrib><creatorcontrib>DOMCHEK, Susan M</creatorcontrib><creatorcontrib>REBBECK, Timothy R</creatorcontrib><creatorcontrib>SIMON, Michael S</creatorcontrib><creatorcontrib>JOHN, Esther M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NINGQI HOU</au><au>YONGLAN ZHENG</au><au>HENNIS, Anselm</au><au>NEMESURE, Barbara</au><au>WU, Suh-Yuh</au><au>CRISTINA LESKE, M</au><au>AMBS, Stefan</au><au>QUN NIU</au><au>JING ZHANG</au><au>PIERCE, Brandon</au><au>COX, Nancy J</au><au>OLOPADE, Olufunmilayo I</au><au>GAMAZON, Eric R</au><au>DEZHENG HUO</au><au>OGUNDIRAN, Temidayo O</au><au>ADEBAMOWO, Clement</au><au>NATHANSON, Katherine L</au><au>DOMCHEK, Susan M</au><au>REBBECK, Timothy R</au><au>SIMON, Michael S</au><au>JOHN, Esther M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Susceptibility to Type 2 Diabetes and Breast Cancer Risk in Women of European and African Ancestry</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>21</volume><issue>3</issue><spage>552</spage><epage>556</epage><pages>552-556</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><coden>CEBPE4</coden><abstract>Epidemiologic studies have reported a positive association between type 2 diabetes (T2D) and breast cancer risk, independent of body weight.
We investigated 40 genetic variants known to be associated with T2D in relation to breast cancer risk among 2,651 breast cancer cases and 2,520 controls of African or European ancestry that were pooled from seven studies.
We found that two T2D risk alleles in Caucasian women (rs5945326-G, rs12518099-C) and one in women of African ancestry (rs7578597-T) were positively associated with breast cancer risk at a nominal significance level of 0.05, whereas two T2D risk alleles were inversely associated with breast cancer risk in Caucasian women (rs1111875-C, rs10923931-T). The composite T2D susceptibility score (the number of risk allele) was not significantly associated with breast cancer risk.
The association between established T2D genetic susceptibility variants and breast cancer risk in women of African or European ancestry is likely weak, if it does exist.
The pleiotropic effects of known T2D risk alleles cannot explain the association between T2D and breast cancer risk.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>22237986</pmid><doi>10.1158/1055-9965.EPI-11-0979</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 2012-03, Vol.21 (3), p.552-556 |
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| subjects | Adult African Continental Ancestry Group - statistics & numerical data Bioindicators Biological and medical sciences Body weight Breast cancer Breast Neoplasms - ethnology Breast Neoplasms - etiology Cancer Case-Control Studies Composite materials Diabetes Complications - ethnology Diabetes Complications - etiology Diabetes mellitus Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance European Continental Ancestry Group - statistics & numerical data Female Females Follow-Up Studies Genetic Predisposition to Disease Humans Medical sciences Middle Aged Prevention Prognosis Risk Factors Tumors |
| title | Genetic Susceptibility to Type 2 Diabetes and Breast Cancer Risk in Women of European and African Ancestry |
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