Regulatory T Cells in Human Ovarian Cancer

Multiple layers of suppressive components including regulatory T (TReg) cells, suppressive antigen-presenting cells, and inhibitory cytokines form suppressive networks in the ovarian cancer microenvironment. It has been demonstrated that as a major suppressive element, TReg cells infiltrate tumor, i...

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Bibliographic Details
Published in:Journal of Oncology 2012-01, Vol.2012 (2012), p.141-147-113
Main Authors: Peng, Dong-Jun, Liu, Rebecca, Zou, Weiping
Format: Article
Language:English
Subjects:
Review
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Summary:Multiple layers of suppressive components including regulatory T (TReg) cells, suppressive antigen-presenting cells, and inhibitory cytokines form suppressive networks in the ovarian cancer microenvironment. It has been demonstrated that as a major suppressive element, TReg cells infiltrate tumor, interact with several types of immune cells, and mediate immune suppression through different molecular and cellular mechanisms. In this paper, we focus on human ovarian cancer and will discuss the nature of TReg cells including their subsets, trafficking, expansion, and function. We will briefly review the development of manipulation of TReg cells in preclinical and clinical settings.
ISSN:1687-8450
1687-8450
DOI:10.1155/2012/345164