Comparison of aerosol formulations of formoterol fumarate and budesonide

The aerodynamic diameter of pharmaceutical aerosols is the main factor governing their deposition in the human respiratory tract. Particle size of the pharmaceutical aerosols is characterized by liquid impingers and Andersen Cascade Impactors. The present study was aimed at comparing two metered dos...

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Bibliographic Details
Published in:Indian journal of pharmaceutical sciences 2011-05, Vol.73 (3), p.282-286
Main Authors: Nirale, N M, Nagarsenker, M S, Mendon, S B, Chanagare, R, Katkurwar, A, Lugade, V
Format: Article
Language:English
Subjects:
Aerosols
Atomic properties
Atoms & subatomic particles
Budesonide
Chemical properties
Comparative analysis
Composition
Drug dosages
Formoterol
Health aspects
Methods
Pharmaceuticals
Research Paper
Surfactants
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Summary:The aerodynamic diameter of pharmaceutical aerosols is the main factor governing their deposition in the human respiratory tract. Particle size of the pharmaceutical aerosols is characterized by liquid impingers and Andersen Cascade Impactors. The present study was aimed at comparing two metered dose inhaler formulation containing formoterol fumarate (6 μg) and budesonide (200 μg). These two formulations were evaluated by using Twin Stage Impinger and Andersen Cascade Impactor. Study revealed that developed metered dose inhaler I formulation of the formoterol fumarate and budesonide had lower mass median aerodynamic diameter and higher fine particle fraction than marketed formulation.
ISSN:0250-474X
1998-3743
DOI:10.4103/0250-474X.93514