CCL7 and CCL21 overexpression in gastric cancer is associated with lymph node metastasis and poor prognosis

• Published in: World journal of gastroenterology : WJG 2012-03, Vol.18 (11), p.1249-1256
• Main Authors: Hwang, Tsann-Long, Lee, Li-Yu, Wang, Chee-Chan, Liang, Ying, Huang, Shu-Fang, Wu, Chi-Ming
• Format: Article
• Language: English
• Subjects: Biomarkers, Tumor - metabolism; Brief; CC趋化因子; Chemokine CCL21 - metabolism; Chemokine CCL7 - metabolism; Chemokine CCL8 - metabolism; Disease Progression; Humans; Kaplan-Meier Estimate; Lymphatic Metastasis - pathology; Middle Aged; Prognosis; Stomach Neoplasms - metabolism; Stomach Neoplasms - mortality; Stomach Neoplasms - pathology; 受体; 复杂网络; 淋巴结; 肿瘤; 胃癌; 过度表达; 预后
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v18.i11.1249

AIM： To investigate how a complex network of CC chemokine ligands （eeLs） and their receptors influence the progression of tumor and metastasis. METHODS： In the present study, we used immunohistochemistry to examine the expression of CCL7, CCL8 and CCL21 in 194 gastric cancer samples and adjacent normal tissues. We analyzed their correlation with tumor metastasis, clinicopathologic parameters and clinical outcome. RESULTS： We found that the higher expression of CCL7 and CCL21 in cancer tissues than in normal tissues was significantly correlated with advanced depth of wall invasion, lymph node metastasis and higher tumornode metastasis stage. Moreover, Kaplan-Meier survival analysis revealed that CCL7 and CCL21 overexpression in cancer tissues was correlated with poor prognosis. CONCLUSION： These results suggest that overexpression of these two CC chemokine ligands is associ- ated with tumor metastasis and serves as a prognostic factor in patients with gastric cancer.