Hypoxia differentially regulates arterial and venous smooth muscle cell proliferation via PDGFR-β and VEGFR-2 expression

Despite intensive research studies, theories have yet to focus on the contribution of hypoxia to patency differences observed clinically between arterial vs. venous grafts. This study investigates the differential hypoxic response of smooth muscle cells (SMC) to hypoxia-derived endothelial cell (EC)...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2012-03, Vol.302 (5), p.H1173-H1184
Main Authors: Chanakira, Alice, Dutta, Raini, Charboneau, Richard, Barke, Roderick, Santilli, Steven M, Roy, Sabita
Format: Article
Language:English
Subjects:
Arteries - metabolism
Cell Hypoxia
Cell Line
Cell Proliferation
Humans
Integrative Cardiovascular Physiology and Pathophysiology
Muscle, Smooth, Vascular - physiology
Proto-Oncogene Proteins c-sis - biosynthesis
Receptor, Platelet-Derived Growth Factor beta - biosynthesis
Vascular Endothelial Growth Factor A - biosynthesis
Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors
Vascular Endothelial Growth Factor Receptor-2 - biosynthesis
Veins - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite intensive research studies, theories have yet to focus on the contribution of hypoxia to patency differences observed clinically between arterial vs. venous grafts. This study investigates the differential hypoxic response of smooth muscle cells (SMC) to hypoxia-derived endothelial cell (EC) growth factors. Initiation of SMC proliferation under hypoxia (
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.00411.2011