The role of autophagy in Parkinson's disease

• Published in: Cold Spring Harbor perspectives in medicine 2012-04, Vol.2 (4), p.a009357-a009357
• Main Authors: Lynch-Day, Melinda A, Mao, Kai, Wang, Ke, Zhao, Mantong, Klionsky, Daniel J
• Format: Article
• Language: English
• Subjects: alpha-Synuclein - genetics; alpha-Synuclein - metabolism; Animals; Autophagy - genetics; Autophagy - physiology; Humans; Mitochondria - metabolism; Mitochondria - physiology; Mitochondrial Degradation; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson Disease - physiopathology; Protein Kinases - genetics; Protein Kinases - metabolism; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism
• ISSN: 2157-1422; 2472-5412
• DOI: 10.1101/cshperspect.a009357

Great progress has been made toward understanding the pathogenesis of Parkinson's disease (PD) during the past two decades, mainly as a consequence of the discovery of specific gene mutations contributing to the onset of PD. Recently, dysregulation of the autophagy pathway has been observed in the brains of PD patients and in animal models of PD, indicating the emerging role of autophagy in this disease. Indeed, autophagy is increasingly implicated in a number of pathophysiologies, including various neurodegenerative diseases. This article will lead you through the connection between autophagy and PD by introducing the concept and physiological function of autophagy, and the proteins related to autosomal dominant and autosomal recessive PD, particularly α-synuclein and PINK1-PARKIN, as they pertain to autophagy.