FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

Lipolysis is defined as the catabolism of triacylglycerols stored in cellular lipid droplets. Recent discoveries of essential lipolytic enzymes and characterization of numerous regulatory proteins and mechanisms have fundamentally changed our perception of lipolysis and its impact on cellular metabo...

Full description

Saved in:
Bibliographic Details
Published in:Cell metabolism 2012-03, Vol.15 (3), p.279-291
Main Authors: Zechner, Rudolf, Zimmermann, Robert, Eichmann, Thomas O., Kohlwein, Sepp D., Haemmerle, Guenter, Lass, Achim, Madeo, Frank
Format: Article
Language:English
Subjects:
Animals
Humans
Lipase - genetics
Lipase - metabolism
Lipid Metabolism - genetics
Lipid Metabolism - physiology
Lipolysis - genetics
Lipolysis - physiology
Review
Signal Transduction - genetics
Signal Transduction - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lipolysis is defined as the catabolism of triacylglycerols stored in cellular lipid droplets. Recent discoveries of essential lipolytic enzymes and characterization of numerous regulatory proteins and mechanisms have fundamentally changed our perception of lipolysis and its impact on cellular metabolism. New findings that lipolytic products and intermediates participate in cellular signaling processes and that “lipolytic signaling” is particularly important in many nonadipose tissues unveil a previously underappreciated aspect of lipolysis, which may be relevant for human disease.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2011.12.018