Treatment strategies for Hodgkin lymphoma recurring following autologous hematopoietic stem cell transplantation

Hodgkin lymphoma (HL) represents one of the great success stories in hematology going from a uniformly fatal disease, to one that is curable in the vast majority of cases. Despite this success, some patients experience relapse. To address this unmet need a variety of agents, classes of drugs, and st...

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Bibliographic Details
Published in:Korean journal of hematology 2012-03, Vol.47 (1), p.8-16
Main Authors: Currin, Erin-Siobhain R, Gopal, Ajay K
Format: Article
Language:English
Subjects:
Review
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Summary:Hodgkin lymphoma (HL) represents one of the great success stories in hematology going from a uniformly fatal disease, to one that is curable in the vast majority of cases. Despite this success, some patients experience relapse. To address this unmet need a variety of agents, classes of drugs, and strategies have demonstrated activity in HL recurring after autologous hematopoietic stem cell transplantation. These include chemotherapeutics (gemcitabine-based combinations, bendamustine), histone deacetylase (HDAC) inhibitors (panobinostat), immunomodulatory agents (lenalidomide), mTOR inhiobitors (everolimus), monoclonal antibodies (rituximab), and antibody-drug conjugates (brentuximab vedotin) as well the potential of long-term disease control via allogeneic transplantation. Such advances reflect our increased understanding of the biology of HL and hold promise for continued improved outcomes for those suffering with this condition.
ISSN:1738-7949
2092-9129
DOI:10.5045/kjh.2012.47.1.8