Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells

Dear Editor, The in vitro propagation （IVP） of animal spermatogonial stem cells （SSCs） provides materials for studying the mechanism of spermatogenesis and for developing novel animal transgenesis and human therapy. The IVP of SSCs is reported to be promoted by exogenous growth factors, among which...

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Bibliographic Details
Published in:Cell research 2012-04, Vol.22 (4), p.773-776
Main Authors: Zhang, Yan, Wang, Si, Wang, Xiuxia, Liao, Shangying, Wu, Yujian, Han, Chunsheng
Format: Article
Language:English
Subjects:
631/136/2434/1822
631/532
631/80/86
Animals
Biomedical and Life Sciences
Cell Biology
Cell Proliferation - drug effects
Cell Survival - genetics
Cells, Cultured
Feeder Cells - metabolism
Fibroblast Growth Factor 2 - biosynthesis
Fibroblast Growth Factor 2 - genetics
Fibroblast Growth Factor 2 - metabolism
Gene Expression Regulation
Gene Knockdown Techniques
Letter to the Editor
Life Sciences
Male
MAP Kinase Signaling System - genetics
Mice
Protein Isoforms - biosynthesis
Protein Isoforms - metabolism
Pyrroles - pharmacology
Spermatogenesis - genetics
Spermatogonia - cytology
Spermatogonia - metabolism
SSCS
Stem cells
Stem Cells - cytology
Stem Cells - metabolism
内源性
培养
增殖
小鼠
精原干细胞
精子发生
胶质细胞源性神经营养因子
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Summary:Dear Editor, The in vitro propagation （IVP） of animal spermatogonial stem cells （SSCs） provides materials for studying the mechanism of spermatogenesis and for developing novel animal transgenesis and human therapy. The IVP of SSCs is reported to be promoted by exogenous growth factors, among which the glial cell-derived neurotrophic factor （GDNF） has been recognized as the single essential one [1, 2]. FGF2,
ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2012.17