Histopathology of Incidental Findings in Beagles Used in Toxicity Studies

The purpose of our publication is to widely communicate the pictures of spontaneous findings occurring in beagles. Spontaneous arteritis occurs commonly in beagles. Frequent sites of arteritis are the heart, spleen, pancreas, epididymis and spinal cord. Morphological similarities between spontaneous...

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Bibliographic Details
Published in:Journal of Toxicologic Pathology 2012, Vol.25(1), pp.103-134
Main Authors: Sato, Junko, Doi, Takuya, Wako, Yumi, Hamamura, Masao, Kanno, Takeshi, Tsuchitani, Minoru, Narama, Isao
Format: Article
Language:English
Subjects:
Arteritis
background
beagle
Canker
Epididymis
Epithelium
Food
Heart
histopathology
incidental
Inflammation
Lung
mucin
Mucosa
Pancreas
Seminiferous tubule
Spinal cord
Spleen
spontaneous
Thyroid
Thyroiditis
Toxicity
Urinary bladder
Vasodilators
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Summary:The purpose of our publication is to widely communicate the pictures of spontaneous findings occurring in beagles. Spontaneous arteritis occurs commonly in beagles. Frequent sites of arteritis are the heart, spleen, pancreas, epididymis and spinal cord. Morphological similarities between spontaneous and drug-induced arterial lesions may cause confusion when evaluating vascular toxicity of chemicals such as vasodilating agents. Focal and minimal inflammatory lesions are occasionally seen in the lung and may be associated with aspiration of food particles or of unknown causes. A cystic change with copious mucin production occurs occasionally in the mucosal epithelium of the gall bladder. Nesidioblastosis is seen rarely in the pancreas of beagles. C-cell complex and lymphocytic thyroiditis are common thyroid lesions. Spontaneous focal hypospermatogenesis and lobular Sertoli-cell-only seminiferous tubules occurring frequently in beagles must be distinguished from drug-induced damage of the seminiferous tubules in toxicity studies. The morphological differences of the female genital system in each cycle need to be understood; therefore, we present the normal features of the cyclic changes of the female genital organs. Further, we provide more information on spontaneous findings in beagles for exact diagnoses in toxicity studies.
ISSN:0914-9198
1881-915X
1347-7404
DOI:10.1293/tox.25.103