Get your fingers out of p53's way

Premature triggering of cell death by p53 has to be avoided. A recent study in EMBO reports demonstrates how the anti‐apoptotic protein Apak represses the expression of the pro‐apoptotic p53 target gene p53AIP1 in non‐stressed cells.

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Published in:EMBO reports 2012-04, Vol.13 (4), p.282-283
Main Authors: Bublik, Débora Rosa, Oren, Moshe
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis Regulatory Proteins - genetics
Apoptosis Regulatory Proteins - metabolism
Binding, Competitive
DNA-Binding Proteins - metabolism
EMBO07
Genes
Hot off the Press
Humans
Inactivation
Introns - genetics
Phosphorylation
Proteins
Signal transduction
Tumor Suppressor Protein p53 - metabolism
Tumors
Upfront
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container_title EMBO reports
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creator Bublik, Débora Rosa
Oren, Moshe
description Premature triggering of cell death by p53 has to be avoided. A recent study in EMBO reports demonstrates how the anti‐apoptotic protein Apak represses the expression of the pro‐apoptotic p53 target gene p53AIP1 in non‐stressed cells.
doi_str_mv 10.1038/embor.2012.33
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subjects Apoptosis
Apoptosis Regulatory Proteins - genetics
Apoptosis Regulatory Proteins - metabolism
Binding, Competitive
DNA-Binding Proteins - metabolism
EMBO07
Genes
Hot off the Press
Humans
Inactivation
Introns - genetics
Phosphorylation
Proteins
Signal transduction
Tumor Suppressor Protein p53 - metabolism
Tumors
Upfront
title Get your fingers out of p53's way
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