Improved nutritional status and bone health after diet-induced weight loss in sedentary osteoarthritis patients: a prospective cohort study

• Published in: European journal of clinical nutrition 2012-04, Vol.66 (4), p.504-509
• Main Authors: Christensen, P, Bartels, E M, Riecke, B F, Bliddal, H, Leeds, A R, Astrup, A, Winther, K, Christensen, R
• Format: Article
• Language: English
• Subjects: Aged; Arthritis; Biological and medical sciences; Body Composition; Body Mass Index; Body weight; Body weight loss; Bone and Bones - metabolism; Bone Density; Bone loss; Bone mineral content; Bone mineral density; Bones; Care and treatment; Clinical Nutrition; Clinical trials; Density; Diet; Diets; Diseases of the osteoarticular system; Energy Intake; Epidemiology; Feeding. Feeding behavior; Female; Ferritin; Ferritins - blood; Food; Fundamental and applied biological sciences. Psychology; Health aspects; Humans; Internal Medicine; Knee; Lean body mass; Male; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Micronutrients; Middle Aged; Nutrition; Nutritional Status; Obesity; Obesity - complications; Obesity - diet therapy; Original; original-article; Osteoarthritis; Osteoarthritis, Knee - blood; Osteoarthritis, Knee - complications; Physiological aspects; Prospective Studies; Public Health; Statistical analysis; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vitamin B 12 - blood; Vitamin B12; Vitamin D; Vitamin D - blood; Weight control; Weight Loss; Weight Reduction Programs
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/ejcn.2011.201

BACKGROUND/OBJECTIVES: Obese subjects are commonly deficient in several micronutrients. Weight loss, although beneficial, may also lead to adverse changes in micronutrient status and body composition. The objective of the study is to assess changes in micronutrient status and body composition in obese individuals after a dietary weight loss program. SUBJECTS/METHODS: As part of a dietary weight loss trial, enrolling 192 obese patients (body mass index >30 kg/m 2 ) with knee osteoarthritis (>50 years of age), vitamin D, ferritin, vitamin B 12 and body composition were measured at baseline and after 16 weeks. All followed an 8-week formula weight-loss diet 415–810 kcal per day, followed by 8 weeks on a hypo-energetic 1200 kcal per day diet with a combination of normal food and formula products. Statistical analyses were based on paired samples in the completer population. RESULTS: A total of 175 patients (142 women), 91%, completed the 16-week program and had a body weight loss of 14.0 kg (95% confidence interval: 13.3–14.7; P