Cardiovascular Activity of Labdane Diterpenes from Andrographis paniculata in Isolated Rat Hearts

The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract significantly reduced coronary perfusion pressure by up to 24.5±3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5±11.4 beats/minute at this dose. Five labdane diterp...

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Bibliographic Details
Published in:BioMed research international 2012-01, Vol.2012 (2012), p.1-5
Main Authors: Awang, Khalijah, Abdullah, Nor Hayati, Hadi, A. Hamid A., Su Fong, Yew
Format: Article
Language:English
Subjects:
Andrographis - chemistry
Andrographis paniculata
Animal models
Animals
Ayurvedic medicine
Blood Pressure - drug effects
Chinese medicine
Diterpenes - chemistry
Diterpenes - pharmacology
Fourier transforms
Health sciences
Heart - drug effects
Heart - physiology
Heart rate
Heart Rate - drug effects
Hypertension
Nitric oxide
Plant Components, Aerial - chemistry
Plant Extracts - chemistry
Plant Extracts - pharmacology
Rats
Rats, Sprague-Dawley
Rodents
Studies
Vasodilation - drug effects
Vasodilator Agents - pharmacology
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Summary:The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract significantly reduced coronary perfusion pressure by up to 24.5±3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5±11.4 beats/minute at this dose. Five labdane diterpenes, 14-deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14-deoxyandrographolide (3), andrographolide (4), and neoandrographolide (5), were isolated from the aerial parts of this medicinal plant. Bioassay-guided studies using animal model showed that compounds, (2) and (3) were responsible for the coronary vasodilatation. This study also showed that andrographolide (4), the major labdane diterpene in this plant, has minimal effects on the heart.
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2012/876458