Nanogel Star Polymer Architectures: A Nanoparticle Platform for Modular Programmable Macromolecular Self-Assembly, Intercellular Transport, and Dual-Mode Cargo Delivery

Nanogel star polymers are developed as a new route for the formation of dual‐mode nanoparticle systems for applications in the areas of synergistic therapeutic delivery, imaged therapeutic delivery, and dual‐mode bioimaging agents. These extremely uniform, structurally versatile, water‐soluble, unim...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2011-10, Vol.23 (39), p.4509-4515
Main Authors: Lee, Victor Y., Havenstrite, Karen, Tjio, Melia, McNeil, Melanie, Blau, Helen M., Miller, Robert D., Sly, Joseph
Format: Article
Language:English
Subjects:
biomedical applications
core/shell nanoparticles
Drug Carriers - chemistry
drug delivery
Formations
Hydrophobic and Hydrophilic Interactions
Modular
Nanoparticles
Nanoparticles - chemistry
Nanostructure
Platforms
Polyethylene Glycols - chemistry
Polyethyleneimine - chemistry
Polymers - chemistry
Polystyrenes - chemistry
Self assembly
Stars
supramolecular materials
Transport
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Summary:Nanogel star polymers are developed as a new route for the formation of dual‐mode nanoparticle systems for applications in the areas of synergistic therapeutic delivery, imaged therapeutic delivery, and dual‐mode bioimaging agents. These extremely uniform, structurally versatile, water‐soluble, unimolecular organic nanoparticles with tunable polyvalency and functionality are preprogrammed to spontaneously upload different types of complex functional macromolecules.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201102371