Host Gene Expression Changes Correlating With Anti—HIV-1 Effects in Human Subjects After Treatment With Peginterferon Alfa-2a

We investigated whether interferon-inducible genes (IFIGs) with known anti—human immunodeficiency virus (HIV) activity in vitro were associated with in vivo virological response in HIV infection. Nine untreated HIV-1—infected volunteers were treated for 12 weeks with peginterferon alfa-2a. A subset...

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Bibliographic Details
Published in:The Journal of infectious diseases 2012-05, Vol.205 (9), p.1443-1447
Main Authors: Hubbard, Jonathan J., Greenwell-Wild, Teresa, Barrett, Lisa, Yang, Jun, Lempicki, Richard A., Wahl, Sharon M., Asmuth, David M., Murphy, Robert L., Pollard, Richard B., Kottilil, Shyam
Format: Article
Language:English
Subjects:
Antiviral Agents - administration & dosage
Antivirals
Biological and medical sciences
Blood
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Regulation - drug effects
HIV
HIV 1
HIV infections
HIV Infections - drug therapy
HIV-1 - isolation & purification
HIV-1 - pathogenicity
HIV/AIDS
Host-Pathogen Interactions - genetics
Human immunodeficiency virus
Humans
Infections
Infectious diseases
Interferon-alpha - administration & dosage
Interferons
Leukocytes, Mononuclear - metabolism
Major and Brief Reports
Medical sciences
Microbiology
Miscellaneous
Polyethylene Glycols - administration & dosage
Polymerase chain reaction
Recombinant Proteins - administration & dosage
RNA, Viral - genetics
RNA, Viral - isolation & purification
Viral Load
Virology
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Summary:We investigated whether interferon-inducible genes (IFIGs) with known anti—human immunodeficiency virus (HIV) activity in vitro were associated with in vivo virological response in HIV infection. Nine untreated HIV-1—infected volunteers were treated for 12 weeks with peginterferon alfa-2a. A subset of IFIGs (23 of 47) increased compared with baseline through 6 weeks beyond therapy, and 10 of the 23 IFIGs significantly inversely correlated (r = -0.7; P < .05) with virological response. The strength of peginterferon alfa-2a-induced IFIG response significantly correlated with declines in HIV load during treatment (r 2 = 0.87, p = .003). This study links HIV virological response to a specific IFIG subset, a potential prognostic indicator in peginterferon alfa-2a—treated patients with HIV infection.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jis211