Synthesis of α-Arylphosphonates using Copper-Catalyzed α-Arylation and Deacylative α-Arylation of β-Ketophosphonates

Efficient methods for the direct arylation and deacylative arylation of β‐ketophosphonates with iodoarenes in presence of a copper(I) or a copper(II) salt as the catalysts have been developed. The corresponding α‐arylphosphonates were obtained in high yields. A tentative mechanism for the deacylativ...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2011-12, Vol.353 (18), p.3340-3346
Main Authors: Rout, Laxmidhar, Regati, Sridhar, Zhao, Cong-Gui
Format: Article
Language:English
Subjects:
arylation
Catalysis
Catalysts
Chemistry
coupling
deacylation
Exact sciences and technology
iodoarenes
Noncondensed benzenic compounds
Organic chemistry
Preparations and properties
Synthesis
Synthesis (chemistry)
α-arylphosphonates
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Summary:Efficient methods for the direct arylation and deacylative arylation of β‐ketophosphonates with iodoarenes in presence of a copper(I) or a copper(II) salt as the catalysts have been developed. The corresponding α‐arylphosphonates were obtained in high yields. A tentative mechanism for the deacylative arylation reaction was proposed on the basis of the experimental data.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201100605